Literature DB >> 30880252

RNA epigenetics and cardiovascular diseases.

Lisa E Dorn1, Simon Tual-Chalot2, Konstantinos Stellos3, Federica Accornero4.   

Abstract

Cardiovascular disease (CVD) remains the leading cause of death in the Western world. Despite advances in the prevention and in the management of CVD, the role of RNA epigenetics in the cardiovascular system has been until recently unexplored. The rapidly expanding research field of RNA modifications has introduced a novel layer of gene regulation in mammalian cells. RNA modifications may control all aspects of RNA metabolism, and their study reveals previously unrecognized regulatory pathways that may determine gene expression at a post-transcriptional level. Understanding the role of RNA modifications in CVD may lead towards a better understanding of disease mechanisms and the development of novel biomarkers or therapeutic strategies. In this review, we highlight the most recent and major reports in the field of RNA methylation and adenosine to inosine RNA editing related to the cardiovascular field and we discuss how this breakthrough will advance the field of precision medicine.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cardiovascular; Epigenetics; RNA

Mesh：

Substances：

Year:  2019        PMID： 30880252      PMCID： PMC6693324          DOI： 10.1016/j.yjmcc.2019.03.010

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  108 in total

1.  Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2.

Authors:  M Higuchi; S Maas; F N Single; J Hartner; A Rozov; N Burnashev; D Feldmeyer; R Sprengel; P H Seeburg
Journal:  Nature       Date:  2000-07-06       Impact factor: 49.962

2.  Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

Authors:  Q Wang; J Khillan; P Gadue; K Nishikura
Journal:  Science       Date:  2000-12-01       Impact factor: 47.728

3.  Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase.

Authors:  Janusz M Bujnicki; Marcin Feder; Monika Radlinska; Robert M Blumenthal
Journal:  J Mol Evol       Date:  2002-10       Impact factor: 2.395

4.  Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster.

Authors:  E Ma; X Q Gu; X Wu; T Xu; G G Haddad
Journal:  J Clin Invest       Date:  2001-03       Impact factor: 14.808

5.  Regulation of alternative splicing by RNA editing.

Authors:  S M Rueter; T R Dawson; R B Emeson
Journal:  Nature       Date:  1999-05-06       Impact factor: 49.962

6.  RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.

Authors:  Zhenji Gan; Liyun Zhao; Liu Yang; Ping Huang; Feng Zhao; Wenjun Li; Yong Liu
Journal:  J Biol Chem       Date:  2006-09-06       Impact factor: 5.157

7.  The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.

Authors:  A D J Scadden
Journal:  Nat Struct Mol Biol       Date:  2005-05-15       Impact factor: 15.369

8.  Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.

Authors:  Punita Bhansali; Jane Dunning; Sarah E Singer; Leora David; Claudia Schmauss
Journal:  J Neurosci       Date:  2007-02-07       Impact factor: 6.167

9.  The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines.

Authors:  Elzbieta Kierzek; Ryszard Kierzek
Journal:  Nucleic Acids Res       Date:  2003-08-01       Impact factor: 16.971

10.  Control of human potassium channel inactivation by editing of a small mRNA hairpin.

Authors:  Tarun Bhalla; Joshua J C Rosenthal; Miguel Holmgren; Robert Reenan
Journal:  Nat Struct Mol Biol       Date:  2004-09-07       Impact factor: 15.369
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  12 in total

1.  From canonical to modified nucleotides: balancing translation and metabolism.

Authors:  Federica Accornero; Robert L Ross; Juan D Alfonzo
Journal:  Crit Rev Biochem Mol Biol       Date:  2020-09-16       Impact factor: 8.250

Review 2.  Epigenetics and vascular diseases.

Authors:  Matthew S Stratton; Floriana Maria Farina; Leonardo Elia
Journal:  J Mol Cell Cardiol       Date:  2019-06-15       Impact factor: 5.000

3.  Improved RNA modification mapping of cellular non-coding RNAs using C- and U-specific RNases.

Authors:  Priti Thakur; Mariana Estevez; Peter A Lobue; Patrick A Limbach; Balasubrahmanyam Addepalli
Journal:  Analyst       Date:  2020-02-03       Impact factor: 4.616

4.  Remodeling of the m6A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy.

Authors:  Scott A Hinger; Jiangbo Wei; Lisa E Dorn; Bryan A Whitson; Paul M L Janssen; Chuan He; Federica Accornero
Journal:  J Mol Cell Cardiol       Date:  2020-11-12       Impact factor: 5.000

5.  ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress.

Authors:  Rajesh Kumari; Roshan Dutta; Prabhat Ranjan; Zainab Gbongbo Suleiman; Sumanta Kumar Goswami; Jing Li; Harish Chandra Pal; Suresh Kumar Verma
Journal:  Front Cardiovasc Med       Date:  2022-01-20

6.  PIWI-Interacting RNA HAAPIR Regulates Cardiomyocyte Death After Myocardial Infarction by Promoting NAT10-Mediated ac4 C Acetylation of Tfec mRNA.

Authors:  Kai Wang; Lu-Yu Zhou; Fang Liu; Liang Lin; Jie Ju; Peng-Chao Tian; Cui-Yun Liu; Xin-Min Li; Xin-Zhe Chen; Tao Wang; Fei Wang; Shao-Cong Wang; Jian Zhang; Yu-Hui Zhang; Jin-Wei Tian; Kun Wang
Journal:  Adv Sci (Weinh)       Date:  2022-02-09       Impact factor: 16.806

Review 7.  Mitochondrial Bioenergetics and Dynamism in the Failing Heart.

Authors:  Giampaolo Morciano; Veronica Angela Maria Vitto; Esmaa Bouhamida; Carlotta Giorgi; Paolo Pinton
Journal:  Life (Basel)       Date:  2021-05-12

Review 8.  Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases.

Authors:  Rajasekharreddy Pala; V T Anju; Madhu Dyavaiah; Siddhardha Busi; Surya M Nauli
Journal:  Int J Nanomedicine       Date:  2020-05-27

Review 9.  Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases.

Authors:  Xuechai Chen; Jianan Wang; Muhammad Tahir; Fangfang Zhang; Yuanyuan Ran; Zongjian Liu; Juan Wang
Journal:  Cell Biosci       Date:  2021-07-27       Impact factor: 7.133

10.  Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease.

Authors:  Nikolaos I Vlachogiannis; Marco Sachse; Georgios Georgiopoulos; Eleftherios Zormpas; Dimitrios Bampatsias; Dimitrios Delialis; Francesca Bonini; George Galyfos; Fragiska Sigala; Kimon Stamatelopoulos; Aikaterini Gatsiou; Konstantinos Stellos
Journal:  J Mol Cell Cardiol       Date:  2021-07-21       Impact factor: 5.000
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