Robert Freedman1, Sharon K Hunter2, Amanda J Law3, Brandie D Wagner4, Angelo D'Alessandro5, Uwe Christians6, Kathleen Noonan2, Anna Wyrwa2, M Camille Hoffman7. 1. Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, CO. Electronic address: Robert.freedman@ucdenver.edu. 2. Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, CO. 3. Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, CO; Department of Cell and Developmental Biology, University of Colorado Denver School of Medicine, Aurora, CO. 4. Department of Biostatistics and Informatics, Colorado School of Public Health (BDW), Aurora, CO. 5. Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, CO. 6. Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, CO. 7. Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, CO; Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO.
Abstract
OBJECTIVE: To assess whether maternal choline decreases effects of mothers' infections on fetal brain circuit development and on expression of infant behavior at 1 year of age. STUDY DESIGN: A cross-sectional study was conducted in a public hospital obstetrics and midwifery service, with prenatal assessments of maternal infection, C-reactive protein, and choline level and postnatal assessments of cerebral neuronal inhibition in 162 newborns. At 1 year, 136 parents completed reports of their child's behavior. RESULTS: Maternal infection at 16 weeks of gestation, experienced by 41% of mothers, raised mean maternal C-reactive protein (d' = 0.47, P = .002) and decreased the development of cerebral inhibition of auditory response at 1 month of age (d' = 0.39, P < .001). Decreased newborn cerebral inhibition manifested as decreased behavioral self-regulation at 1 year. Greater choline levels in mothers with infections were associated with improved newborn inhibition of auditory cerebral response, mitigating the effect of infection (β = -0.34 [95% CI, -5.35 to -0.14], P = .002). At 1 year of age, children of mothers with infection and greater gestational choline levels had improved development of self-regulation, approaching the level of children of mothers without infection (β = 0.29 [95% CI 0.05-0.54], P = .03). CONCLUSIONS: Greater maternal choline, recommended by the American Medical Association as a prenatal supplement, is associated with greater self-regulation among infants who experienced common maternal infections during gestation. Behavioral problems with diminished self-regulation often lead to referrals to pediatricians and might lead to later mental illness.
OBJECTIVE: To assess whether maternal choline decreases effects of mothers' infections on fetal brain circuit development and on expression of infant behavior at 1 year of age. STUDY DESIGN: A cross-sectional study was conducted in a public hospital obstetrics and midwifery service, with prenatal assessments of maternal infection, C-reactive protein, and choline level and postnatal assessments of cerebral neuronal inhibition in 162 newborns. At 1 year, 136 parents completed reports of their child's behavior. RESULTS:Maternal infection at 16 weeks of gestation, experienced by 41% of mothers, raised mean maternal C-reactive protein (d' = 0.47, P = .002) and decreased the development of cerebral inhibition of auditory response at 1 month of age (d' = 0.39, P < .001). Decreased newborn cerebral inhibition manifested as decreased behavioral self-regulation at 1 year. Greater choline levels in mothers with infections were associated with improved newborn inhibition of auditory cerebral response, mitigating the effect of infection (β = -0.34 [95% CI, -5.35 to -0.14], P = .002). At 1 year of age, children of mothers with infection and greater gestational choline levels had improved development of self-regulation, approaching the level of children of mothers without infection (β = 0.29 [95% CI 0.05-0.54], P = .03). CONCLUSIONS: Greater maternal choline, recommended by the American Medical Association as a prenatal supplement, is associated with greater self-regulation among infants who experienced common maternal infections during gestation. Behavioral problems with diminished self-regulation often lead to referrals to pediatricians and might lead to later mental illness.
Authors: M Camille Hoffman; Sharon K Hunter; Angelo D'Alessandro; Kathleen Noonan; Anna Wyrwa; Robert Freedman Journal: Psychol Med Date: 2019-07-31 Impact factor: 7.723
Authors: Sharon K Hunter; M Camille Hoffman; Angelo D'Alessandro; Kathleen Noonan; Anna Wyrwa; Robert Freedman; Amanda J Law Journal: Psychol Med Date: 2019-12-02 Impact factor: 7.723
Authors: Sharon K Hunter; M Camille Hoffman; Angelo D'Alessandro; Anna Wyrwa; Kathleen Noonan; Steven H Zeisel; Amanda J Law; Robert Freedman Journal: Psychol Med Date: 2021-01-25 Impact factor: 10.592
Authors: Nicole E Marshall; Barbara Abrams; Linda A Barbour; Patrick Catalano; Parul Christian; Jacob E Friedman; William W Hay; Teri L Hernandez; Nancy F Krebs; Emily Oken; Jonathan Q Purnell; James M Roberts; Hora Soltani; Jacqueline Wallace; Kent L Thornburg Journal: Am J Obstet Gynecol Date: 2021-12-27 Impact factor: 10.693
Authors: Sharon K Hunter; M Camille Hoffman; Angelo D'Alessandro; Victoria K Walker; Madeline Balser; Kathleen Noonan; Amanda J Law; Robert Freedman Journal: J Psychiatr Res Date: 2021-06-18 Impact factor: 5.250