Literature DB >> 30879165

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Erin Morgan1, John T Gamble2, Martin C Pearce2, Daniel J Elson2, Robert L Tanguay2,3,4, Siva Kumar Kolluri2,3,4, Norbert O Reich5.   

Abstract

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.

Entities:  

Keywords:  Apoptosis; Bcl-2; Hollow gold nanoshells; NuBCP; Peptide delivery; Resistant cancer

Mesh：

Substances：

Year:  2019        PMID： 30879165      PMCID： PMC8918063          DOI： 10.1007/s10495-019-01531-1

Source DB:  PubMed          Journal:  Apoptosis        ISSN： 1360-8185            Impact factor:   4.677


  27 in total

1.  Ultrasensitive nanosensors based on upconversion nanoparticles for selective hypoxia imaging in vivo upon near-infrared excitation.

Authors:  Jianan Liu; Yong Liu; Wenbo Bu; Jiwen Bu; Yong Sun; Jiulin Du; Jianlin Shi
Journal:  J Am Chem Soc       Date:  2014-06-27       Impact factor: 15.419

2.  Corrigendum to 'Concomitant delivery of paclitaxel and NuBCP-9 peptide for synergistic enhancement of cancer therapy' NANO 14 (2018) 1301-1313.

Authors:  Dikshi Gupta; Manoj Kumar; Priyanka Tyagi; Sumeet Kapoor; Amit Tyagi; Tarani Kanta Barman; Surender Kharbanda; Donald Kufe; Harpal Singh
Journal:  Nanomedicine       Date:  2018-07-24       Impact factor: 5.307

3.  Intracellular delivery of peptide cargos using polyhydroxybutyrate based biodegradable nanoparticles: Studies on antitumor efficacy of BCL-2 converting peptide, NuBCP-9.

Authors:  Sumeet Kapoor; Dikishi Gupta; Manoj Kumar; Sapna Sharma; Amit K Gupta; M M Misro; Harpal Singh
Journal:  Int J Pharm       Date:  2016-08-01       Impact factor: 5.875

4.  Intracellular delivery of peptide cargos using iron oxide based nanoparticles: studies on antitumor efficacy of a BCL-2 converting peptide, NuBCP-9.

Authors:  Manoj Kumar; Gurpal Singh; Sapna Sharma; Dikshi Gupta; Vivek Bansal; Vikas Arora; Madhusudan Bhat; Sandeep K Srivastava; Sameer Sapra; Surender Kharbanda; Amit K Dinda; Harpal Singh
Journal:  Nanoscale       Date:  2014-11-06       Impact factor: 7.790

5.  Quinoxaline-Based Polymer Dots with Ultrabright Red to Near-Infrared Fluorescence for In Vivo Biological Imaging.

Authors:  Hong-Yi Liu; Pei-Jing Wu; Shih-Yu Kuo; Chuan-Pin Chen; En-Hao Chang; Chang-Yi Wu; Yang-Hsiang Chan
Journal:  J Am Chem Soc       Date:  2015-08-10       Impact factor: 15.419

6.  Novel polymeric nanoparticles for intracellular delivery of peptide Cargos: antitumor efficacy of the BCL-2 conversion peptide NuBCP-9.

Authors:  Manoj Kumar; Dikshi Gupta; Gurpal Singh; Sapna Sharma; Madhusudan Bhat; C K Prashant; A K Dinda; Surender Kharbanda; Donald Kufe; Harpal Singh
Journal:  Cancer Res       Date:  2014-04-16       Impact factor: 12.701

Review 7.  Ligand-targeted therapeutics in anticancer therapy.

Authors:  Theresa M Allen
Journal:  Nat Rev Cancer       Date:  2002-10       Impact factor: 60.716

8.  Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

Authors:  Bingzhen Lin; Siva Kumar Kolluri; Feng Lin; Wen Liu; Young-Hoon Han; Xihua Cao; Marcia I Dawson; John C Reed; Xiao-kun Zhang
Journal:  Cell       Date:  2004-02-20       Impact factor: 41.582

Review 9.  Zebrafish: A complete animal model to enumerate the nanoparticle toxicity.

Authors:  Chiranjib Chakraborty; Ashish Ranjan Sharma; Garima Sharma; Sang-Soo Lee
Journal:  J Nanobiotechnology       Date:  2016-08-20       Impact factor: 10.435

10.  Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells.

Authors:  Martin C Pearce; John T Gamble; Prasad R Kopparapu; Edmond F O'Donnell; Monica J Mueller; Hyo Sang Jang; Julie A Greenwood; Arnold C Satterthwait; Robert L Tanguay; Xiao-Kun Zhang; Siva Kumar Kolluri
Journal:  Oncotarget       Date:  2018-05-25
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  2 in total

1.  VIPERnano: Improved Live Cell Intracellular Protein Tracking.

Authors:  Erin Morgan; Julia Doh; Kimberly Beatty; Norbert Reich
Journal:  ACS Appl Mater Interfaces       Date:  2019-10-01       Impact factor: 9.229

Review 2.  The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics.

Authors:  John T Gamble; Daniel J Elson; Juliet A Greenwood; Robyn L Tanguay; Siva K Kolluri
Journal:  Biology (Basel)       Date:  2021-03-24
  2 in total

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