Literature DB >> 30879022

Misclassification of Myocardial Injury as Myocardial Infarction: Implications for Assessing Outcomes in Value-Based Programs.

Cian McCarthy1, Sean Murphy1, Joshua A Cohen1, Saad Rehman1, Maeve Jones-O'Connor1, David S Olshan1, Avinainder Singh2, Muthiah Vaduganathan3, James L Januzzi4, Jason H Wasfy4.   

Abstract

Importance: Similar to other patients with acute myocardial infarction, patients with type 2 myocardial infarction (T2MI) are included in several value-based programs, including the Hospital Readmissions Reduction Program and the Hospital Value-Based Purchasing Program. To our knowledge, whether nonischemic myocardial injury is being misclassified as T2MI is unknown and may have implications for these programs. Objective: To determine whether patients with nonischemic myocardial injury are being miscoded as having T2MI and if this has implications for 30-day readmission and mortality rates. Design, Settings, and Participants: Using the new International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code, we identified patients who were coded as having T2MI between October 2017 and May 2018 at Massachusetts General Hospital. Strict adjudication using the fourth universal definition of MI was then applied. Main outcome and Measures: Clinical adjudication of T2MI and 30-day readmission and mortality rates as a function of T2MI or nonischemic myocardial injury.
Results: Of 633 patients, 369 (58.3%) were men and 514 (81.2%) were white. After strict adjudication, 359 (56.7%) had T2MI, 265 (41.9%) had myocardial injury, 6 (0.9%) had type 1 MI, and 3 (0.5%) had unstable angina. Patients with T2MI had a higher prevalence of cardiovascular comorbidities than those with myocardial injury. Patients with T2MI and myocardial injury had high in-hospital mortality rates (10.6% and 8.7%, respectively; P = .50). Of those discharged alive (563 [88.9%]), 30-day readmission rates (22.7% vs 21.1%; P = .68) and mortality rates (4.4% vs 7.4%; P = .14) were comparable among patients with T2MI and myocardial injury. Conclusions and Relevance: A substantial percentage of patients coded as having T2MI actually have myocardial injury. Both conditions have high 30-day readmission and mortality rates. Including patients with high-risk myocardial injury may have substantial implications for value-based programs.

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Mesh:

Year:  2019        PMID: 30879022      PMCID: PMC6537800          DOI: 10.1001/jamacardio.2019.0716

Source DB:  PubMed          Journal:  JAMA Cardiol            Impact factor:   14.676


  6 in total

1.  Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I.

Authors:  Yader Sandoval; Stephen W Smith; Anne Sexter; Sarah E Thordsen; Charles A Bruen; Michelle D Carlson; Kenneth W Dodd; Brian E Driver; Yan Hu; Katherine Jacoby; Benjamin K Johnson; Sara A Love; Johanna C Moore; Karen Schulz; Nathaniel L Scott; Fred S Apple
Journal:  Am J Med       Date:  2017-07-21       Impact factor: 4.965

Review 2.  Fourth Universal Definition of Myocardial Infarction (2018).

Authors:  Kristian Thygesen; Joseph S Alpert; Allan S Jaffe; Bernard R Chaitman; Jeroen J Bax; David A Morrow; Harvey D White
Journal:  J Am Coll Cardiol       Date:  2018-08-25       Impact factor: 24.094

3.  Predicting In-Hospital Mortality in Patients With Acute Myocardial Infarction.

Authors:  Robert L McNamara; Kevin F Kennedy; David J Cohen; Deborah B Diercks; Mauro Moscucci; Stephen Ramee; Tracy Y Wang; Traci Connolly; John A Spertus
Journal:  J Am Coll Cardiol       Date:  2016-08-09       Impact factor: 24.094

4.  Type 2 Myocardial Infarction and the Hospital Readmission Reduction Program.

Authors:  Cian P McCarthy; Muthiah Vaduganathan; Avinainder Singh; Zirui Song; Ron Blankstein; Hanna K Gaggin; Jason H Wasfy; James L Januzzi
Journal:  J Am Coll Cardiol       Date:  2018-09-04       Impact factor: 24.094

5.  Clinical Profile of Acute Myocardial Infarction Patients Included in the Hospital Readmissions Reduction Program.

Authors:  Lila M Martin; James L Januzzi; Ryan W Thompson; Timothy G Ferris; Jagmeet P Singh; Vijeta Bhambhani; Jason H Wasfy
Journal:  J Am Heart Assoc       Date:  2018-08-21       Impact factor: 5.501

6.  Trends in 30-Day Readmission Rates for Medicare and Non-Medicare Patients in the Era of the Affordable Care Act.

Authors:  Suveen Angraal; Rohan Khera; Shengfan Zhou; Yongfei Wang; Zhenqiu Lin; Kumar Dharmarajan; Nihar R Desai; Susannah M Bernheim; Elizabeth E Drye; Khurram Nasir; Leora I Horwitz; Harlan M Krumholz
Journal:  Am J Med       Date:  2018-09-07       Impact factor: 4.965

  6 in total
  18 in total

1.  Development of a Portable Tool to Identify Patients With Atrial Fibrillation Using Clinical Notes From the Electronic Medical Record.

Authors:  Rashmee U Shah; R Kannan Mutharasan; Faraz S Ahmad; Anna G Rosenblatt; Hawkins C Gay; Benjamin A Steinberg; Mark Yandell; Martin Tristani-Firouzi; Jake Klewer; Rebeka Mukherjee; Donald M Lloyd-Jones
Journal:  Circ Cardiovasc Qual Outcomes       Date:  2020-10-14

2.  Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation.

Authors:  Yader Sandoval; Bradley R Lewis; Ramila A Mehta; Olatunde Ola; Jonathan D Knott; Laura De Michieli; Ashok Akula; Ronstan Lobo; Eric H Yang; S Michael Gharacholou; Marshall Dworak; Erika Crockford; Nicholas Rastas; Eric Grube; Swetha Karturi; Scott Wohlrab; David O Hodge; Tahir Tak; Charles Cagin; Rajiv Gulati; Allan S Jaffe
Journal:  Circulation       Date:  2022-05-10       Impact factor: 39.918

3.  Acute Myocardial Infarction Cohorts Defined by International Classification of Diseases, Tenth Revision Versus Diagnosis-Related Groups: Analysis of Diagnostic Agreement and Quality Measures in an Integrated Health System.

Authors:  Andrew E Levy; Andrew Hammes; Debra L Anoff; Joshua D Raines; Natalie M Beck; Eric W Rudofker; Kimberly J Marshall; Jessica D Nensel; John C Messenger; Frederick A Masoudi; Read G Pierce; Larry A Allen; Karen S Ream; P Michael Ho
Journal:  Circ Cardiovasc Qual Outcomes       Date:  2021-03-03

4.  Characterizing Bias Due to Differential Exposure Ascertainment in Electronic Health Record Data.

Authors:  Rebecca A Hubbard; Elle Lett; Gloria Y F Ho; Jessica Chubak
Journal:  Health Serv Outcomes Res Methodol       Date:  2021-01-04

5.  Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction.

Authors:  Katia Bruxvoort; Jeff Slezak; Lei Qian; Lina S Sy; Bradley Ackerson; Kristi Reynolds; Runxin Huang; Zendi Solano; William Towner; Cheryl Mercado; Steven J Jacobsen
Journal:  JAMA       Date:  2022-04-05       Impact factor: 157.335

6.  Exosomes Derived From Epigallocatechin Gallate-Treated Cardiomyocytes Attenuated Acute Myocardial Infarction by Modulating MicroRNA-30a.

Authors:  Chan Zhang; Xiaowen Gan; Ronggan Liang; Jie Jian
Journal:  Front Pharmacol       Date:  2020-02-26       Impact factor: 5.810

7.  Trends in High- and Low-Value Cardiovascular Diagnostic Testing in Fee-for-Service Medicare, 2000-2016.

Authors:  Vinay Kini; Timea Viragh; David Magid; Frederick A Masoudi; Ali Moghtaderi; Bernard Black
Journal:  JAMA Netw Open       Date:  2019-10-02

Review 8.  Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury.

Authors:  Andrew P DeFilippis; Andrew R Chapman; Nicholas L Mills; James A de Lemos; Armin Arbab-Zadeh; L Kristin Newby; David A Morrow
Journal:  Circulation       Date:  2019-08-16       Impact factor: 29.690

9.  Patient Characteristics and Outcomes of Type 2 Myocardial Infarction During Heart Failure Hospitalizations in the United States.

Authors:  Salik Nazir; Abdul Mannan Khan Minhas; Ishan S Kamat; Robert W Ariss; George V Moukarbel; Juan Carlos Plana Gomez; Savitri Fedson; Ajith Nair; Biykem Bozkurt; Hani Jneid
Journal:  Am J Med       Date:  2021-06-30       Impact factor: 5.928

10.  Impact of Different Electronic Cohort Definitions to Identify Patients With Atrial Fibrillation From the Electronic Medical Record.

Authors:  Rashmee U Shah; Rebeka Mukherjee; Yue Zhang; Aubrey E Jones; Jennifer Springer; Ian Hackett; Benjamin A Steinberg; Donald M Lloyd-Jones; Wendy W Chapman
Journal:  J Am Heart Assoc       Date:  2020-02-26       Impact factor: 5.501

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