| Literature DB >> 30878881 |
Natalia Sánchez-Romero1, Pilar Sainz-Arnal2, Iris Pla-Palacín1, Pablo Royo Dachary1, Helen Almeida1, Cristina Pastor3, Daniela Rubio Soto4, Milagros Chico Rodriguez5, Emma Olmedo Arbizu5, Lourdes Bengochea Martinez5, Trinidad Serrano-Aulló1, Pedro M Baptista6.
Abstract
The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.Keywords: ECM; Growth factors; Liver development; Mechanobiology; Progenitor cell; Stem cell; Stem cell niche
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Year: 2019 PMID： 30878881 DOI： 10.1016/j.diff.2019.03.001
Source DB: PubMed Journal: Differentiation ISSN： 0301-4681 Impact factor: 3.880