Jenalee R Doom1, Brie M Reid2, Estela Blanco3, Raquel Burrows4, Betsy Lozoff5, Sheila Gahagan6. 1. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI; Department of Pediatrics, University of Michigan, Ann Arbor, MI. Electronic address: jrdoom@umich.edu. 2. Institute of Child Development, University of Minnesota, Minneapolis, MN. 3. Department of Pediatrics, University of California San Diego, San Diego, CA; Doctoral Program in Public Health, School of Public Health, Universidad de Chile, Santiago, Chile. 4. Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos, Santiago, Chile. 5. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI; Department of Pediatrics, University of Michigan, Ann Arbor, MI. 6. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI; Department of Pediatrics, University of California San Diego, San Diego, CA.
Abstract
OBJECTIVE: To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence. STUDY DESIGN: Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence. RESULTS: Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12). CONCLUSIONS: These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.
OBJECTIVE: To prospectively assess whether the infantpsychosocial environment was associated with cardiometabolic risk as early as adolescence. STUDY DESIGN:Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence. RESULTS: Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infantpsychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infantpsychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12). CONCLUSIONS: These findings demonstrate that a poorer infantpsychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.
Authors: Paul Zimmet; K George Mm Alberti; Francine Kaufman; Naoko Tajima; Martin Silink; Silva Arslanian; Gary Wong; Peter Bennett; Jonathan Shaw; Sonia Caprio Journal: Pediatr Diabetes Date: 2007-10 Impact factor: 4.866
Authors: Jason José Bendezú; Casey D Calhoun; Meghan Vinograd; Megan W Patterson; Karen D Rudolph; Matteo Giletta; Paul Hastings; Matthew K Nock; George M Slavich; Mitchell J Prinstein Journal: Dev Psychobiol Date: 2022-03 Impact factor: 3.038
Authors: Ágnes Péterfalvi; Nándor Németh; Róbert Herczeg; Tamás Tényi; Attila Miseta; Boldizsár Czéh; Maria Simon Journal: Front Psychol Date: 2019-08-06