Literature DB >> 30875054

Authentication and Assessment of Contamination in Ancient DNA.

Gabriel Renaud1, Mikkel Schubert1, Susanna Sawyer1, Ludovic Orlando2,3.   

Abstract

Contamination from both present-day humans and postmortem microbial sources is a common challenge in ancient DNA studies. Here we present a suite of tools to assist in the assessment of contamination in ancient DNA data sets. These tools perform standard tests of authenticity of ancient DNA data including detecting the presence of postmortem damage signatures in sequence alignments and quantifying the amount of present-day human contamination.

Entities:  

Keywords:  Ancient DNA; Contamination; DICE; Postmortem damage; Schmutzi; mapDamage2.0

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Year:  2019        PMID： 30875054     DOI： 10.1007/978-1-4939-9176-1_17

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  2 in total

1.  Competitive mapping allows for the identification and exclusion of human DNA contamination in ancient faunal genomic datasets.

Authors:  Tatiana R Feuerborn; Eleftheria Palkopoulou; Tom van der Valk; Johanna von Seth; Arielle R Munters; Patrícia Pečnerová; Marianne Dehasque; Irene Ureña; Erik Ersmark; Vendela Kempe Lagerholm; Maja Krzewińska; Ricardo Rodríguez-Varela; Anders Götherström; Love Dalén; David Díez-Del-Molino
Journal:  BMC Genomics       Date:  2020-11-30       Impact factor: 3.969

2.  Development and Optimization of a Silica Column-Based Extraction Protocol for Ancient DNA.

Authors:  Marianne Dehasque; Patrícia Pečnerová; Vendela Kempe Lagerholm; Erik Ersmark; Gleb K Danilov; Peter Mortensen; Sergey Vartanyan; Love Dalén
Journal:  Genes (Basel)       Date:  2022-04-13       Impact factor: 4.141
  2 in total

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