Fabian Echterdiek1, Daniel Kitterer2, M Dominik Alscher3, Vedat Schwenger2, Bettina Ruckenbrod4, Martin Bald4, Joerg Latus2. 1. Department of Nephrology, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart, Germany. f.echterdiek@klinikum-stuttgart.de. 2. Department of Nephrology, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart, Germany. 3. Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany. 4. Olga Children's Hospital, Department of Pediatric Nephrology, Klinikum Stuttgart, Stuttgart, Germany.
Abstract
BACKGROUND: Hantavirus infections are endemic worldwide, and its incidence in Europe has been steadily increasing. In Western Europe, hantavirus infections are typically caused by Puumala hantavirus and cause nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. Up to now, there is only little data about the course of acute NE in children, but it has been suggested that hantavirus infections take a lighter course in children when compared to adults. We performed a retrospective analysis of adults and children diagnosed with acute NE in two counties in South-Western Germany to investigate if there are differences in the course of the disease. METHODS: We reviewed the medical records of 295 adults and 22 children with acute NE regarding clinical presentation, laboratory findings, complications and outcome. RESULTS: Acute kidney injury (AKI) and thrombocytopenia occurred at similar frequencies and severity in both groups. Sudden onset of fever and back/loin pain were two of the three most common symptoms in both adults and children. However, adults presented more frequently with arthralgia and visual disturbances, whereas abdominal pain and nausea/vomiting could be detected more often in children. No significant differences were found in the incidence of complications (haemodialysis, long-term outcome of kidney function, length of hospital stay). CONCLUSIONS: The clinical course of acute NE was similar in adults and children with high frequency of AKI as well as thrombocytopenia, but with full recovery of all patients.
BACKGROUND: Hantavirus infections are endemic worldwide, and its incidence in Europe has been steadily increasing. In Western Europe, hantavirus infections are typically caused by Puumala hantavirus and cause nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. Up to now, there is only little data about the course of acute NE in children, but it has been suggested that hantavirus infections take a lighter course in children when compared to adults. We performed a retrospective analysis of adults and children diagnosed with acute NE in two counties in South-Western Germany to investigate if there are differences in the course of the disease. METHODS: We reviewed the medical records of 295 adults and 22 children with acute NE regarding clinical presentation, laboratory findings, complications and outcome. RESULTS: Acute kidney injury (AKI) and thrombocytopenia occurred at similar frequencies and severity in both groups. Sudden onset of fever and back/loin pain were two of the three most common symptoms in both adults and children. However, adults presented more frequently with arthralgia and visual disturbances, whereas abdominal pain and nausea/vomiting could be detected more often in children. No significant differences were found in the incidence of complications (haemodialysis, long-term outcome of kidney function, length of hospital stay). CONCLUSIONS: The clinical course of acute NE was similar in adults and children with high frequency of AKI as well as thrombocytopenia, but with full recovery of all patients.
Authors: Tuula K Outinen; Satu Mäkelä; Jan Clement; Antti Paakkala; Ilkka Pörsti; Jukka Mustonen Journal: Nephron Date: 2015-06-26 Impact factor: 2.847
Authors: Niko Braun; Michael Haap; Dietrich Overkamp; Martin Kimmel; Mark Dominik Alscher; Hendrik Lehnert; Christian S Haas Journal: Nephrol Dial Transplant Date: 2010-03-11 Impact factor: 5.992
Authors: Antti Vaheri; Heikki Henttonen; Liina Voutilainen; Jukka Mustonen; Tarja Sironen; Olli Vapalahti Journal: Rev Med Virol Date: 2012-07-03 Impact factor: 6.989
Authors: Olli Vapalahti; Jukka Mustonen; Ake Lundkvist; Heikki Henttonen; Alexander Plyusnin; Antti Vaheri Journal: Lancet Infect Dis Date: 2003-10 Impact factor: 25.071
Authors: Joerg Latus; Matthias Schwab; Evelina Tacconelli; Friedrich-Michael Pieper; Daniel Wegener; Juergen Dippon; Simon Müller; David Zakim; Stephan Segerer; Daniel Kitterer; Martin Priwitzer; Barbara Mezger; Birgit Walter-Frank; Angela Corea; Albrecht Wiedenmann; Stefan Brockmann; Christoph Pöhlmann; M Dominik Alscher; Niko Braun Journal: Emerg Infect Dis Date: 2015-01 Impact factor: 6.883