Literature DB >> 3087411

A novel disialoganglioside (IV3NeuAcIII6NeuAcLc4) of human adenocarcinoma and the monoclonal antibody (FH9) defining this disialosyl structure.

Y Fukushi, E Nudelman, S B Levery, T Higuchi, S Hakomori.   

Abstract

This ganglioside is highly immunogenic, and immunization of mice with this disialoganglioside fraction coated on Salmonella minnesota followed by fusion of immunized spleen cells with mouse myeloma and selection of the hybridoma by positive reactivity with the purified disialoganglioside resulted in the establishment of a hybridoma secreting immunoglobulin G2a antibody FH9 that reacts specifically with the ganglioside antigen above but not with monosialosyllactotetraosylceramide I (IV3NeuAcLc4), monosialosyllactotetraosylceramide II (III6NeuAcLc4), or any other gangliosides tested.

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Year:  1986        PMID： 3087411     DOI： 10.1021/bi00358a018

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  10 in total

Review 1.  The glycosynapse.

Authors:  Sen-itiroh Hakomori Si
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-02       Impact factor: 11.205

Review 2.  Multifarious roles of sialic acids in immunity.

Authors:  Ajit Varki; Pascal Gagneux
Journal:  Ann N Y Acad Sci       Date:  2012-04       Impact factor: 5.691

Review 3.  In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands.

Authors:  R Renkonen; P Mattila; M L Majuri; J Räbinä; S Toppila; J Renkonen; L Hirvas; J Niittymäki; J P Turunen; O Renkonen; T Paavonen
Journal:  Glycoconj J       Date:  1997-08       Impact factor: 2.916

Review 4.  Traveling for the glycosphingolipid path.

Authors:  S Hakomori
Journal:  Glycoconj J       Date:  2000 Jul-Sep       Impact factor: 2.916

5.  Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers.

Authors:  Motohiro Senda; Akihiro Ito; Akiko Tsuchida; Tomoko Hagiwara; Tsuguhiro Kaneda; Yoko Nakamura; Kenji Kasama; Makoto Kiso; Kazuhiro Yoshikawa; Yoko Katagiri; Yoshinari Ono; Manabu Ogiso; Takeshi Urano; Keiko Furukawa; Shinichi Oshima; Koichi Furukawa
Journal:  Biochem J       Date:  2007-03-15       Impact factor: 3.857

Review 6.  Structure and function of glycosphingolipids and sphingolipids: recollections and future trends.

Authors:  Sen-itiroh Hakomori
Journal:  Biochim Biophys Acta       Date:  2007-09-06

7.  Monoclonal antibody (5F3) defining renal cell carcinoma-associated antigen disialosyl globopentaosylceramide (V3NeuAcIV6NeuAcGb5), and distribution pattern of the antigen in tumor and normal tissues.

Authors:  A Ito; S Saito; T Masuko; M Oh-Eda; T Matsuura; M Satoh; F M Nejad; T Enomoto; S Orikasa; S I Hakomori
Journal:  Glycoconj J       Date:  2001-06       Impact factor: 2.916

Review 8.  The trail of my studies on glycoproteins from enterokinase to tumor markers.

Authors:  Ikuo Yamashina
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

Review 9.  Exploration of the Sialic Acid World.

Authors:  Roland Schauer; Johannis P Kamerling
Journal:  Adv Carbohydr Chem Biochem       Date:  2018-11-28       Impact factor: 12.200

10.  Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells.

Authors:  Akiko Tsuchida; Motohiro Senda; Akihiro Ito; Seiichi Saito; Makoto Kiso; Takayuki Ando; Anne Harduin-Lepers; Akio Matsuda; Keiko Furukawa; Koichi Furukawa
Journal:  Sci Rep       Date:  2018-05-04       Impact factor: 4.379
  10 in total

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