Literature DB >> 30871545

The role of long non-coding RNAs in the pathogenesis of hereditary diseases.

Peter Sparber1, Alexandra Filatova2, Mira Khantemirova3,4, Mikhail Skoblov2,5.   

Abstract

BACKGROUND: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown.
RESULTS: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role.
CONCLUSIONS: Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.

Entities:  

Keywords:  Gene regulation; Hereditary disease; Long non-coding RNA; Medical genetics; lncRNA

Year:  2019        PMID： 30871545      PMCID： PMC6416829          DOI： 10.1186/s12920-019-0487-6

Source DB:  PubMed          Journal:  BMC Med Genomics        ISSN： 1755-8794            Impact factor:   3.063


  110 in total

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Authors:  M Runte; A Hüttenhofer; S Gross; M Kiefmann; B Horsthemke; K Buiting
Journal:  Hum Mol Genet       Date:  2001-11-01       Impact factor: 6.150

2.  Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.

Authors:  John L Rinn; Michael Kertesz; Jordon K Wang; Sharon L Squazzo; Xiao Xu; Samantha A Brugmann; L Henry Goodnough; Jill A Helms; Peggy J Farnham; Eran Segal; Howard Y Chang
Journal:  Cell       Date:  2007-06-29       Impact factor: 41.582

3.  An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.

Authors:  Paula D Ladd; Leslie E Smith; Natalia A Rabaia; James M Moore; Sara A Georges; R Scott Hansen; Randi J Hagerman; Flora Tassone; Stephen J Tapscott; Galina N Filippova
Journal:  Hum Mol Genet       Date:  2007-10-06       Impact factor: 6.150

4.  Primary structure, neural-specific expression, and dendritic location of human BC200 RNA.

Authors:  H Tiedge; W Chen; J Brosius
Journal:  J Neurosci       Date:  1993-06       Impact factor: 6.167

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Review 6.  Silver-Russell syndrome.

Authors:  Emma L Wakeling
Journal:  Arch Dis Child       Date:  2011-02-24       Impact factor: 3.791

7.  LincRNA-p21 suppresses target mRNA translation.

Authors:  Je-Hyun Yoon; Kotb Abdelmohsen; Subramanya Srikantan; Xiaoling Yang; Jennifer L Martindale; Supriyo De; Maite Huarte; Ming Zhan; Kevin G Becker; Myriam Gorospe
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8.  Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus.

Authors:  A Figurov; L D Pozzo-Miller; P Olafsson; T Wang; B Lu
Journal:  Nature       Date:  1996-06-20       Impact factor: 49.962

9.  Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer.

Authors:  Lin Liu; Jian Yang; Xuchao Zhu; Dan Li; Zhongwei Lv; Xiaoping Zhang
Journal:  FEBS J       Date:  2016-05-12       Impact factor: 5.542

10.  A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy.

Authors:  Daphne S Cabianca; Valentina Casa; Beatrice Bodega; Alexandros Xynos; Enrico Ginelli; Yujiro Tanaka; Davide Gabellini
Journal:  Cell       Date:  2012-04-26       Impact factor: 41.582
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  20 in total

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2.  Medical genomics at the Systems Biology and Bioinformatics (SBB-2019) school.

Authors:  Yuriy L Orlov; Elena N Voropaeva; Ming Chen; Ancha V Baranova
Journal:  BMC Med Genomics       Date:  2020-09-18       Impact factor: 3.063

3.  Medical genomics research at BGRS-2018.

Authors:  Ancha V Baranova; Vadim V Klimontov; Andrey Y Letyagin; Yuriy L Orlov
Journal:  BMC Med Genomics       Date:  2019-03-13       Impact factor: 3.063

4.  Cancer Susceptibility Candidate 9 (CASC9) Promotes Colorectal Cancer Carcinogenesis via mTOR-Dependent Autophagy and Epithelial-Mesenchymal Transition Pathways.

Authors:  Md Zahirul Islam Khan; Helen Ka Wai Law
Journal:  Front Mol Biosci       Date:  2021-05-04

5.  MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis.

Authors:  Ping Nan; Yugui Niu; Xiuhua Wang; Qiang Li
Journal:  Onco Targets Ther       Date:  2019-08-26       Impact factor: 4.147

6.  Identification of New Potential LncRNA Biomarkers in Hirschsprung Disease.

Authors:  Ana Torroglosa; Leticia Villalba-Benito; Raquel María Fernández; Berta Luzón-Toro; María José Moya-Jiménez; Guillermo Antiñolo; Salud Borrego
Journal:  Int J Mol Sci       Date:  2020-08-02       Impact factor: 5.923

7.  lncRNA SOX2-OT regulates laryngeal cancer cell proliferation, migration and invasion and induces apoptosis by suppressing miR-654.

Authors:  Guang Li; Chunchen Pan; Jiaqiang Sun; Guanglun Wan; Jingwu Sun
Journal:  Exp Ther Med       Date:  2020-03-06       Impact factor: 2.447

Review 8.  Functions and properties of nuclear lncRNAs-from systematically mapping the interactomes of lncRNAs.

Authors:  Chia-Yu Guh; Yu-Hung Hsieh; Hsueh-Ping Chu
Journal:  J Biomed Sci       Date:  2020-03-17       Impact factor: 8.410

9.  Long Non-Coding RNA ASB16-AS1 Functions as a miR-760 Sponge to Facilitate the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression.

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Review 10.  Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases.

Authors:  Kang-Hoon Lee; Hyeon-Ji Hwang; Je-Yoel Cho
Journal:  Int J Mol Sci       Date:  2020-11-06       Impact factor: 5.923
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