Literature DB >> 30870825

Coincidence time resolution of 30 ps FWHM using a pair of Cherenkov-radiator-integrated MCP-PMTs.

R Ota1, K Nakajima, I Ogawa, Y Tamagawa, H Shimoi, M Suyama, T Hasegawa.   

Abstract

Radiation detectors dedicated to time-of-flight positron emission tomography (PET) have been developed, and coincidence time resolution (CTR) of sub-100 ps full width at half maximum (FWHM) has been achieved by carefully optimizing scintillators and photodetectors. Achieving a CTR of 30 ps FWHM by using a pair of annihilation γ-rays would allow us to directly localize the annihilation point within an accuracy of 4.5 mm. Such direct localization can potentially eliminate the requirement of image reconstruction processes in clinical PET systems, which would have a huge impact on clinical protocols and molecular imaging. To obtain such a high CTR, researchers have investigated the use of prompt emissions such as Cherenkov radiation and hot-intra band luminescence. Although it is still challenging to achieve a CTR of 30 ps FWHM even with a Cherenkov-based detector, the experimentally measured CTR is approaching the goal. In this work, we developed a Cherenkov-radiator-integrated micro-channel plate photomultiplier tube (CRI-MCP-PMT), where there are no optical boundaries between the radiator and photocathode, and its timing performance was investigated. By removing the optical boundaries, reflections are eliminated and transmission to the photocathode is improved, resulting in high timing capability. As a result, a CTR of 30.1  ±  2.4 ps FWHM, which is equivalent to a position resolution of 4.5  ±  0.3 mm along a line of response (LOR), was obtained by using a pair of CRI-MCP-PMTs.

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Year:  2019        PMID: 30870825     DOI: 10.1088/1361-6560/ab0fce

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  8 in total

Review 1.  Photon counting detectors and their applications ranging from particle physics experiments to environmental radiation monitoring and medical imaging.

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Journal:  Radiol Phys Technol       Date:  2021-03-19

2.  Roadmap toward the 10 ps time-of-flight PET challenge.

Authors:  Paul Lecoq; Christian Morel; John O Prior; Dimitris Visvikis; Stefan Gundacker; Etiennette Auffray; Peter Križan; Rosana Martinez Turtos; Dominique Thers; Edoardo Charbon; Joao Varela; Christophe de La Taille; Angelo Rivetti; Dominique Breton; Jean-François Pratte; Johan Nuyts; Suleman Surti; Stefaan Vandenberghe; Paul Marsden; Katia Parodi; Jose Maria Benlloch; Mathieu Benoit
Journal:  Phys Med Biol       Date:  2020-10-22       Impact factor: 3.609

3.  Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET.

Authors:  Gerard Ariño-Estrada; Emilie Roncali; Aaron R Selfridge; Junwei Du; Jaroslaw Glodo; Kanai S Shah; Simon R Cherry
Journal:  IEEE Trans Radiat Plasma Med Sci       Date:  2020-09-17

4.  Ultrafast timing enables reconstruction-free positron emission imaging.

Authors:  Sun Il Kwon; Ryosuke Ota; Eric Berg; Fumio Hashimoto; Kyohei Nakajima; Izumi Ogawa; Yoichi Tamagawa; Tomohide Omura; Tomoyuki Hasegawa; Simon R Cherry
Journal:  Nat Photonics       Date:  2021-10-14       Impact factor: 39.728

5.  Integration of polarization in the LUTDavis model for optical Monte Carlo simulation in radiation detectors.

Authors:  Carlotta Trigila; Emilie Roncali
Journal:  Phys Med Biol       Date:  2021-10-22       Impact factor: 4.174

6.  Performance assessment of the 2 γpositronium imaging with the total-body PET scanners.

Authors:  P Moskal; D Kisielewska; R Y Shopa; Z Bura; J Chhokar; C Curceanu; E Czerwiński; M Dadgar; K Dulski; J Gajewski; A Gajos; M Gorgol; R Del Grande; B C Hiesmayr; B Jasińska; K Kacprzak; A Kamińska; Ł Kapłon; H Karimi; G Korcyl; P Kowalski; N Krawczyk; W Krzemień; T Kozik; E Kubicz; P Małczak; M Mohammed; Sz Niedźwiecki; M Pałka; M Pawlik-Niedźwiecka; M Pędziwiatr; L Raczyński; J Raj; A Ruciński; S Sharma; S Shivani; M Silarski; M Skurzok; E Ł Stępień; S Vandenberghe; W Wiślicki; B Zgardzińska
Journal:  EJNMMI Phys       Date:  2020-06-30

7.  High resolution detectors for whole-body PET scanners by using dual-ended readout.

Authors:  Zheng Liu; Ming Niu; Zhonghua Kuang; Ning Ren; San Wu; Longhan Cong; Xiaohui Wang; Ziru Sang; Crispin Williams; Yongfeng Yang
Journal:  EJNMMI Phys       Date:  2022-04-21

8.  Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners.

Authors:  Nikos Efthimiou; Kris Thielemans; Elise Emond; Chris Cawthorne; Stephen J Archibald; Charalampos Tsoumpas
Journal:  EJNMMI Phys       Date:  2020-06-19
  8 in total

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