Literature DB >> 30870553

A thermoresponsive nanocarrier for mitochondria-targeted drug delivery.

Dongqing Wang1, Hui Huang, Mengxue Zhou, Huiru Lu, Jun Chen, Young-Tae Chang, Jimin Gao, Zhifang Chai, Yi Hu.   

Abstract

Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer strategy.

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Year:  2019        PMID： 30870553     DOI： 10.1039/c9cc00603f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

Review 1.  Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials.

Authors:  Hongxu Liu; Theeraphop Prachyathipsakul; Thameez M Koyasseril-Yehiya; Stephanie P Le; S Thayumanavan
Journal:  Mater Horiz       Date:  2022-01-04       Impact factor: 13.266

2.  Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex.

Authors:  Weili Peng; Zeping Zhang; Minzhi Rong; Mingqiu Zhang
Journal:  Polymers (Basel)       Date:  2019-11-07       Impact factor: 4.329

3.  Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy.

Authors:  Riku Kawasaki; Keita Yamana; Risako Shimada; Kouta Sugikawa; Atsushi Ikeda
Journal:  ACS Omega       Date:  2021-01-19

4.  Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer.

Authors:  Lifo Ruan; Jun Chen; Chuanchao Du; Huiru Lu; Jiayu Zhang; Xiaomeng Cai; Rui Dou; Wenchu Lin; Zhifang Chai; Guangjun Nie; Yi Hu
Journal:  Bioact Mater       Date:  2021-11-04

5.  Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer.

Authors:  Ying Bi; Miao Wang; Lirong Peng; Lifo Ruan; Mengxue Zhou; Yi Hu; Jun Chen; Jimin Gao
Journal:  Nanoscale Adv       Date:  2019-12-17

6.  Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy.

Authors:  Rajeshwari Tiwari; Prashant S Shinde; Sreejesh Sreedharan; Anik Kumar Dey; Katherine A Vallis; Santosh B Mhaske; Sumit Kumar Pramanik; Amitava Das
Journal:  Chem Sci       Date:  2020-12-23       Impact factor: 9.825

Review 7.  Membrane Trafficking and Subcellular Drug Targeting Pathways.

Authors:  Ajay Kumar; Anas Ahmad; Akshay Vyawahare; Rehan Khan
Journal:  Front Pharmacol       Date:  2020-05-27       Impact factor: 5.810

Review 8.  Nanogel: A Versatile Nano-Delivery System for Biomedical Applications.

Authors:  Yanlong Yin; Ben Hu; Xiao Yuan; Li Cai; Huile Gao; Qian Yang
Journal:  Pharmaceutics       Date:  2020-03-23       Impact factor: 6.321

9.  Gold(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane Ligands as Thermoresponsive Anticancer Agents in Human Colon Cells.

Authors:  Javier Quero; Francesco Ruighi; Jesús Osada; M Concepción Gimeno; Elena Cerrada; Maria Jesús Rodriguez-Yoldi
Journal:  Biomedicines       Date:  2021-12-06
  9 in total

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