Literature DB >> 30867323

"Inactive" ingredients in oral medications.

Daniel Reker1,2,3, Steven M Blum1,4,5, Christoph Steiger1,2,3, Kevin E Anger4, Jamie M Sommer6, John Fanikos6, Giovanni Traverso7,2,3,4,8.   

Abstract

Oral forms of medications contain "inactive" ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30867323     DOI： 10.1126/scitranslmed.aau6753

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  11 in total

Review 1.  Foundations of gastrointestinal-based drug delivery and future developments.

Authors:  Jacqueline N Chu; Giovanni Traverso
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2021-11-16       Impact factor: 46.802

Review 2.  Merging data curation and machine learning to improve nanomedicines.

Authors:  Chen Chen; Zvi Yaari; Elana Apfelbaum; Piotr Grodzinski; Yosi Shamay; Daniel A Heller
Journal:  Adv Drug Deliv Rev       Date:  2022-02-18       Impact factor: 17.873

3.  Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications.

Authors:  Daniel Reker; Steven M Blum; Peter Wade; Christoph Steiger; Giovanni Traverso
Journal:  Pharm Res       Date:  2020-10-29       Impact factor: 4.200

4.  Computationally guided high-throughput design of self-assembling drug nanoparticles.

Authors:  Daniel Reker; Yulia Rybakova; Ameya R Kirtane; Ruonan Cao; Jee Won Yang; Natsuda Navamajiti; Apolonia Gardner; Rosanna M Zhang; Tina Esfandiary; Johanna L'Heureux; Thomas von Erlach; Elena M Smekalova; Dominique Leboeuf; Kaitlyn Hess; Aaron Lopes; Jaimie Rogner; Joy Collins; Siddartha M Tamang; Keiko Ishida; Paul Chamberlain; DongSoo Yun; Abigail Lytton-Jean; Christian K Soule; Jaime H Cheah; Alison M Hayward; Robert Langer; Giovanni Traverso
Journal:  Nat Nanotechnol       Date:  2021-03-25       Impact factor: 40.523

Review 5.  Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.

Authors:  Maria Luisa Caballero; Matthew S Krantz; Santiago Quirce; Elizabeth J Phillips; Cosby A Stone
Journal:  J Allergy Clin Immunol Pract       Date:  2021-03-15

6.  Understanding Concomitant Physical and Chemical Transformations of Simvastatin During Dry Ball Milling.

Authors:  Dattatray Modhave; Isha Saraf; Anjali Karn; Amrit Paudel
Journal:  AAPS PharmSciTech       Date:  2020-05-21       Impact factor: 3.246

7.  Evaluation of Medication Package Inserts in Ethiopia.

Authors:  Haftom Gebregergs Hailu; Mengistie Yirsaw Gobezie; Khalid Beshir Tuem; Hildana Tewolde Gebremichael; Solomon Ahmed Mohammed
Journal:  J Environ Public Health       Date:  2022-01-19

8.  Intradermal testing increases the accuracy of an immediate-type cefaclor hypersensitivity diagnosis.

Authors:  Ji-Hyang Lee; Chan Sun Park; Min Ju Pyo; A Ryang Lee; Eunyong Shin; Young-Sang Yoo; Woo-Jung Song; Tae-Bum Kim; You-Sook Cho; Hyouk-Soo Kwon
Journal:  World Allergy Organ J       Date:  2022-04-01       Impact factor: 4.084

9.  Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation.

Authors:  Emanuela Bellu; Nicia Diaz; Martin Kralovič; Radek Divin; Giorgia Sarais; Angela Fadda; Rosanna Satta; Maria Antonia Montesu; Serenella Medici; Antonio Brunetti; Ana Rita Pinheiro Barcessat; Taťána Jarošíková; Jiří Rulc; Evzen Amler; Valentina Margarita; Paola Rappelli; Margherita Maioli
Journal:  Plants (Basel)       Date:  2022-06-15

10.  Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Authors:  Daniel Reker; Yunhua Shi; Ameya R Kirtane; Kaitlyn Hess; Grace J Zhong; Evan Crane; Chih-Hsin Lin; Robert Langer; Giovanni Traverso
Journal:  Cell Rep       Date:  2020-03-17       Impact factor: 9.423
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.