| Literature DB >> 3086715 |
M Stefanini, C Mondello, L Tessera, V Capuano, B R Guerra, F Nuzzo.
Abstract
Three UV-sensitive (UVs) mutants isolated from a CHO cell line were analyzed for survival after exposure to H2O2, EMS, MMC, CCNU, X-rays and for mutation induction after UV-irradiation. The UVs mutants showed normal sensitivities to EMS and H2O2, whereas they were hypersensitive to the bifunctional alkylating agents MMC and CCNU and to hypoxic X-irradiation. Compared to parental cells, one of the UV-sensitive clones showed approximately 3- and 7-fold enhancement in the mutagenic response per unit UV dose for 6-thioguanine and ouabain resistance, respectively.Entities:
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Year: 1986 PMID： 3086715 DOI： 10.1016/0165-7992(86)90108-9
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433