Literature DB >> 3086423

Serum thyrotropin by ultrasensitive immunoradiometric assay and serum free thyroid hormones in pregnancy.

A Pacchiarotti, E Martino, L Bartalena, L Buratti, C Mammoli, F Strigini, F Fruzzetti, G B Melis, A Pinchera.   

Abstract

Variations of serum TSH, measured by an ultrasensitive immunoradiometric assay, of serum total and free thyroid hormones and of thyroxine-binding globulin (TBG) and sex hormone-binding globulin (SHBG) were investigated in a group of 18 normal women before and during pregnancy. A gradual increase of total thyroid hormones, TBG and SHBG was observed, while mean serum free thyroxine and free triiodothyronine progressively decreased. Serum TSH concentrations were comprised within the normal range throughout pregnancy, although a small but significant increase was found in the 2nd and 3rd trimester. These changes may represent a compensatory mechanism to meet the increased demand for thyroid hormones in pregnancy and must be taken into account for a correct evaluation of thyroid function during gestation.

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Year:  1986        PMID： 3086423     DOI： 10.1007/BF03348095

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  31 in total

1.  Human serum thyrotrophin measurement by ultrasensitive immunoradiometric assay as a first-line test in the evaluation of thyroid function.

Authors:  E Martino; G Bambini; L Bartalena; C Mammoli; F Aghini-Lombardi; L Baschieri; A Pinchera
Journal:  Clin Endocrinol (Oxf)       Date:  1986-02       Impact factor: 3.478

2.  Effects of oral contraceptives and pregnancy on thyroid function.

Authors:  D L Schatz; H C Palter; C S Russell
Journal:  Can Med Assoc J       Date:  1968-11-09       Impact factor: 8.262

3.  Serum free thyroxine concentration and free thyroid hormone indices in normal pregnancy.

Authors:  M R Hopton; K Ashwell; I V Scott; J S Harrop
Journal:  Clin Endocrinol (Oxf)       Date:  1983-04       Impact factor: 3.478

4.  Study of a mechanism responsible for anomalous results for free thyroxin by some analog assays for subjects with albumin deficiency.

Authors:  T J Wilke
Journal:  Clin Chem       Date:  1984-11       Impact factor: 8.327

5.  Serum free thyroxine in pregnancy.

Authors:  A Kurtz; K Dwyer; R Ekins
Journal:  Br Med J       Date:  1979-09-01

6.  Total and free thyroxine and triiodothyronine in normal and complicated pregnancy.

Authors:  R Osathanondh; D Tulchinsky; I J Chopra
Journal:  J Clin Endocrinol Metab       Date:  1976-01       Impact factor: 5.958

7.  Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area.

Authors:  G F Fenzi; C Ceccarelli; E Macchia; F Monzani; L Bartalena; C Giani; P Ceccarelli; F Lippi; L Baschieri; A Pinchera
Journal:  Clin Endocrinol (Oxf)       Date:  1985-08       Impact factor: 3.478

8.  Comparison of thyroid function in each trimester of pregnancy with the use of triiodothyronine uptake, thyroxine iodine, free thyroxine, and free thyroxine index.

Authors:  J A Souma; D C Niejadlik; S Cottrell; S Rankel
Journal:  Am J Obstet Gynecol       Date:  1973-08-01       Impact factor: 8.661

9.  Measurement of serum free thyroxine by RIA in various clinical states.

Authors:  L E Braverman; C M Abreau; P Brock; R Kleinmann; L Fournier; G Odstrchel; H J Schoemaker
Journal:  J Nucl Med       Date:  1980-03       Impact factor: 10.057

10.  Components of the total serum thyroid hormone concentrations during pregnancy: high free thyroxine and blunted thyrotropin (TSH) response to TSH-releasing hormone in the first trimester.

Authors:  J Guillaume; G C Schussler; J Goldman
Journal:  J Clin Endocrinol Metab       Date:  1985-04       Impact factor: 5.958
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  4 in total

1.  The application of an immunoradiometric assay of plasma thyrotropin (TSH-IRMA) in molar pregnancy.

Authors:  A Berghout; E Endert; W M Wiersinga; J L Touber
Journal:  J Endocrinol Invest       Date:  1988-01       Impact factor: 4.256

2.  Postpartum thyroid dysfunction in an Italian population residing in an area of mild iodine deficiency.

Authors:  E Roti; L Bianconi; E Gardini; R Minelli; M L De Franco; A Bacchi Modena; D Bresciani; P Villa; T M Neri; M Savi
Journal:  J Endocrinol Invest       Date:  1991-09       Impact factor: 4.256

3.  Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns.

Authors:  E Roti; E Gardini; R Minelli; L Bianconi; M Flisi
Journal:  J Endocrinol Invest       Date:  1991-01       Impact factor: 4.256

Review 4.  Clinical use of sensitive assays for thyroid-stimulating hormone.

Authors:  P A Masters; R J Simons
Journal:  J Gen Intern Med       Date:  1996-02       Impact factor: 5.128
  4 in total

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