Literature DB >> 30864132

Characterization of Arabinosyl Transfer Reactions in the Biosynthesis of Mycobacterial Cell Envelope (Lipo)Polysaccharides.

Shiva Kumar Angala1, Mary Jackson2.   

Abstract

D-Arabinofuranose is a major glycosyl constituent of mycobacteria found in two essential cell envelope heteropolysaccharides, arabinogalactan and lipoarabinomannan. Seven different arabinosyltransferases at least are required to synthesize the arabinan domain of these two major glycans. Because of their interest from the perspective of drug development, these enzymes have been the object of intense investigations. In this chapter, we describe the protocols used to perform nonradioactive arabinosyltransferase assays with synthetic acceptor and donor substrates and characterize the enzymatic products of the reactions by mass spectrometry.

Entities:  

Keywords:  Arabinosyltransferase; D-Arabinose; Lipid donor; Mycobacteria; Synthetic arabinoside acceptor

Mesh：

Substances：

Year:  2019        PMID： 30864132      PMCID： PMC6432646          DOI： 10.1007/978-1-4939-9154-9_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  19 in total

1.  The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.

Authors:  V E Escuyer; M A Lety; J B Torrelles; K H Khoo; J B Tang; C D Rithner; C Frehel; M R McNeil; P J Brennan; D Chatterjee
Journal:  J Biol Chem       Date:  2001-10-24       Impact factor: 5.157

2.  Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Authors:  Vadim Makarov; Giulia Manina; Katarina Mikusova; Ute Möllmann; Olga Ryabova; Brigitte Saint-Joanis; Neeraj Dhar; Maria Rosalia Pasca; Silvia Buroni; Anna Paola Lucarelli; Anna Milano; Edda De Rossi; Martina Belanova; Adela Bobovska; Petronela Dianiskova; Jana Kordulakova; Claudia Sala; Elizabeth Fullam; Patricia Schneider; John D McKinney; Priscille Brodin; Thierry Christophe; Simon Waddell; Philip Butcher; Jakob Albrethsen; Ida Rosenkrands; Roland Brosch; Vrinda Nandi; Sowmya Bharath; Sheshagiri Gaonkar; Radha K Shandil; Venkataraman Balasubramanian; Tanjore Balganesh; Sandeep Tyagi; Jacques Grosset; Giovanna Riccardi; Stewart T Cole
Journal:  Science       Date:  2009-03-19       Impact factor: 47.728

3.  AftD, a novel essential arabinofuranosyltransferase from mycobacteria.

Authors:  Henrieta Skovierová; Gérald Larrouy-Maumus; Jian Zhang; Devinder Kaur; Nathalie Barilone; Jana Korduláková; Martine Gilleron; Stéphanie Guadagnini; Martina Belanová; Marie-Christine Prevost; Brigitte Gicquel; Germain Puzo; Delphi Chatterjee; Patrick J Brennan; Jérôme Nigou; Mary Jackson
Journal:  Glycobiology       Date:  2009-08-04       Impact factor: 4.313

4.  Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.

Authors:  Libin Shi; Roukun Zhou; Zhentong Liu; Todd L Lowary; Peter H Seeberger; Bridget L Stocker; Dean C Crick; Kay-Hooi Khoo; Delphi Chatterjee
Journal:  J Bacteriol       Date:  2008-06-13       Impact factor: 3.490

5.  Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.

Authors:  Luke J Alderwick; Mathias Seidel; Hermann Sahm; Gurdyal S Besra; Lothar Eggeling
Journal:  J Biol Chem       Date:  2006-04-04       Impact factor: 5.157

6.  The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module.

Authors:  Luke J Alderwick; Georgina S Lloyd; Hemza Ghadbane; John W May; Apoorva Bhatt; Lothar Eggeling; Klaus Fütterer; Gurdyal S Besra
Journal:  PLoS Pathog       Date:  2011-02-24       Impact factor: 6.823

7.  High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.

Authors:  Thierry Christophe; Mary Jackson; Hee Kyoung Jeon; Denis Fenistein; Monica Contreras-Dominguez; Jaeseung Kim; Auguste Genovesio; Jean-Philippe Carralot; Fanny Ewann; Eun Hye Kim; Sae Yeon Lee; Sunhee Kang; Min Jung Seo; Eun Jung Park; Henrieta Skovierová; Ha Pham; Giovanna Riccardi; Ji Youn Nam; Laurent Marsollier; Marie Kempf; Marie-Laure Joly-Guillou; Taegwon Oh; Won Kyung Shin; Zaesung No; Ulf Nehrbass; Roland Brosch; Stewart T Cole; Priscille Brodin
Journal:  PLoS Pathog       Date:  2009-10-30       Impact factor: 6.823

8.  Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase.

Authors:  Pui-Hang Tam; Gurdyal S Besra; Todd L Lowary
Journal:  Chembiochem       Date:  2008-01-25       Impact factor: 3.164

9.  Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Authors:  Mathias Seidel; Luke J Alderwick; Helen L Birch; Hermann Sahm; Lothar Eggeling; Gurdyal S Besra
Journal:  J Biol Chem       Date:  2007-03-26       Impact factor: 5.157

10.  Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.

Authors:  Helen L Birch; Luke J Alderwick; Apoorva Bhatt; Doris Rittmann; Karin Krumbach; Albel Singh; Yu Bai; Todd L Lowary; Lothar Eggeling; Gurdyal S Besra
Journal:  Mol Microbiol       Date:  2008-07-04       Impact factor: 3.501
View more
  2 in total

Review 1.  Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It?

Authors:  Julio Flores; Juan Carlos Cancino; Leslie Chavez-Galan
Journal:  Front Microbiol       Date:  2021-04-15       Impact factor: 5.640

2.  Use of Synthetic Glycolipids to Probe the Number and Position of Arabinan Chains on Mycobacterial Arabinogalactan.

Authors:  Shiva Kumar Angala; Maju Joe; Michael R McNeil; Avraham Liav; Todd L Lowary; Mary Jackson
Journal:  ACS Chem Biol       Date:  2020-12-31       Impact factor: 5.100
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.