Jone Bjornestad1, Kristina O Lavik2, Larry Davidson3, Aslak Hjeltnes4, Christian Moltu2, Marius Veseth4. 1. Department of Social Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway. 2. Department of Psychiatry, District General Hospital of F⊘rde, F⊘rde, Norway. 3. School of Medicine, Yale University, New Haven, CT, USA. 4. Department of Clinical Psychology, University of Bergen, Bergen, Norway.
Abstract
Background: The literature on antipsychotic medication in psychosis lack systematization of the empirical knowledge base on patients' subjective experiences of using antipsychotic drugs. Such investigations are pivotal to inform large-scale trials with clinically relevant hypotheses and to illuminate clinical implications for different sub-groups of individuals.Aims: To re-analyze and summarize existing qualitative research literature on patient perspectives of using antipsychotic medication.Method: A systematic literature search was performed in September 2018 (Protocol registration no. CRD42017074394). Using an existing framework of meta-analyzing qualitative research, full text evaluation was conducted for 41 articles. Thirty-two articles were included for the final synthesis. Results: Four meta-themes were identified: (1) short-term benefits; (2) adverse effects and coping processes; (3) surrender and autonomy; (4) long-term compromise of functional recovery.Conclusions: While largely positive about acute and short-term use, patients are more skeptical about using antipsychotic drugs in the longer term. The latter specifically relates to processes of functional and social recovery. The clinical conversations about antipsychotic medication need to include evaluations of contexts of patient experience level, patient autonomy processes, patient values and risk preferences, and patient knowledge and knowledge needs in addition to assessing the severity of symptoms of psychosis.
Background: The literature on antipsychotic medication in psychosis lack systematization of the empirical knowledge base on patients' subjective experiences of using antipsychotic drugs. Such investigations are pivotal to inform large-scale trials with clinically relevant hypotheses and to illuminate clinical implications for different sub-groups of individuals.Aims: To re-analyze and summarize existing qualitative research literature on patient perspectives of using antipsychotic medication.Method: A systematic literature search was performed in September 2018 (Protocol registration no. CRD42017074394). Using an existing framework of meta-analyzing qualitative research, full text evaluation was conducted for 41 articles. Thirty-two articles were included for the final synthesis. Results: Four meta-themes were identified: (1) short-term benefits; (2) adverse effects and coping processes; (3) surrender and autonomy; (4) long-term compromise of functional recovery.Conclusions: While largely positive about acute and short-term use, patients are more skeptical about using antipsychotic drugs in the longer term. The latter specifically relates to processes of functional and social recovery. The clinical conversations about antipsychotic medication need to include evaluations of contexts of patient experience level, patient autonomy processes, patient values and risk preferences, and patient knowledge and knowledge needs in addition to assessing the severity of symptoms of psychosis.
Authors: Christine Henriksen Oedegaard; Ana Lorena Ruano; Anne Blindheim; Marius Veseth; Brynjulf Stige; Larry Davidson; Ingunn Marie Stadskleiv Engebretsen Journal: Int J Ment Health Syst Date: 2022-04-04