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Literature DB >> 3086116

Diabetes alters drug metabolism--in vivo studies in a streptozotozin-diabetic rat model.

Abstract

The influence of experimental streptozotozin-induced diabetes on hepatic drug metabolism in vivo has been studied in rats, using 14CO2-exhalation after 14C-aminopyrine injection. Male diabetic rats showed a decreased (-18%), females an increased (+19%) 14CO2-exhalation compared to controls, indicating altered hepatic drug metabolism due to diabetes.

Entities: Chemical Disease Species

Mesh：

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Year: 1986 PMID： 3086116 DOI： 10.1007/bf01946703

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

23 in total

1. The continuous kinetic determination of p-nitroanisole O-demethylation in hemoglobin-free perfused rat liver.

Authors: R G Thurman; D P Marazzo; L S Jones; F C Kauffman
Journal: J Pharmacol Exp Ther Date: 1977-05 Impact factor: 4.030

2. Kinetics of CO2-HCO3 minus in normal adult males.

Authors: H S Winchell; H Stahelin; N Kusubov; B Slanger; M Fish; M Pollycove; J H Lawrence
Journal: J Nucl Med Date: 1970-12 Impact factor: 10.057

3. Effect of exercise on human CO2-HCO3 minus kinetics.

Authors: B H Slanger; N Kusubov; H S Winchell
Journal: J Nucl Med Date: 1970-12 Impact factor: 10.057

4. Altered metabolism of 7-ethoxycoumarin by hepatic, pulmonary, and intestinal microsomes from streptozotocin-diabetic rats.

Authors: W A Al-Turk; S J Stohs; E B Roche
Journal: Drug Metab Dispos Date: 1980 Jan-Feb Impact factor: 3.922

Review 5. Clinical utility of breath tests for the assessment of hepatic function.

Authors: A L Baker; A N Kotake; D A Schoeller
Journal: Semin Liver Dis Date: 1983-11 Impact factor: 6.115

6. Effect of adrenalectomy on the cytochrome P-450 population of diabetic rat liver.

Authors: M R Past; D E Cook; J F Hofert
Journal: Horm Metab Res Date: 1983-06 Impact factor: 2.936

7. Activities of hepatic and extrahepatic microsomal mixed function oxidase enzymes in diabetic and gonadectomized-diabetic rats.

Authors: W A Al-Turk; S J Stohs; E B Roche
Journal: Gen Pharmacol Date: 1981

8. Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat.

Authors: B H Lauterburg; J Bircher
Journal: J Pharmacol Exp Ther Date: 1976-02 Impact factor: 4.030

9. Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450.

Authors: M R Past; D E Cook
Journal: Biochem Pharmacol Date: 1982-10-15 Impact factor: 5.858