Literature DB >> 30860635

Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer.

Claudia Riccardi1, Albert Meyer2, Jean-Jacques Vasseur2, Irene Russo Krauss1,3, Luigi Paduano1,3, Rosario Oliva1, Luigi Petraccone1, François Morvan2, Daniela Montesarchio1.   

Abstract

With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin-binding aptamer (TBA) analogue (cycTBA) has been prepared by exploiting a copper(I)-assisted azide-alkyne cycloaddition. The markedly increased serum resistance and exceptional thermal stability of the G-quadruplex versus TBA were associated with halved thrombin inhibition, which suggested that some flexibility in the TBA structure was necessary for protein recognition.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  G-quadruplexes; aptamers; click chemistry; cyclization; molecular recognition

Mesh：

Substances：

Year:  2019        PMID： 30860635     DOI： 10.1002/cbic.201900045

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  8 in total

1.  Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies.

Authors:  Claudia Riccardi; Federica D'Aria; Filomena Anna Digilio; Maria Rosaria Carillo; Jussara Amato; Dominga Fasano; Laura De Rosa; Simona Paladino; Mariarosa Anna Beatrice Melone; Daniela Montesarchio; Concetta Giancola
Journal:  Int J Mol Sci       Date:  2022-04-27       Impact factor: 6.208

Review 2.  Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition.

Authors:  Claudia Riccardi; Ettore Napolitano; Domenica Musumeci; Daniela Montesarchio
Journal:  Molecules       Date:  2020-11-10       Impact factor: 4.411

Review 3.  Overview of the Therapeutic Potential of Aptamers Targeting Coagulation Factors.

Authors:  Max Liu; Khalequz Zaman; Yolanda M Fortenberry
Journal:  Int J Mol Sci       Date:  2021-04-09       Impact factor: 5.923

4.  Circular L-RNA aptamer promotes target recognition and controls gene activity.

Authors:  Danyang Ji; Kaixin Lyu; Haizhou Zhao; Chun Kit Kwok
Journal:  Nucleic Acids Res       Date:  2021-07-21       Impact factor: 16.971

5.  Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides.

Authors:  Matic Kovačič; Peter Podbevšek; Hisae Tateishi-Karimata; Shuntaro Takahashi; Naoki Sugimoto; Janez Plavec
Journal:  Nucleic Acids Res       Date:  2020-04-17       Impact factor: 16.971

6.  Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs.

Authors:  Claudia Riccardi; Domenica Musumeci; Chiara Platella; Rosa Gaglione; Angela Arciello; Daniela Montesarchio
Journal:  Int J Mol Sci       Date:  2020-03-13       Impact factor: 5.923

Review 7.  Aptamers Chemistry: Chemical Modifications and Conjugation Strategies.

Authors:  Fadwa Odeh; Hamdi Nsairat; Walhan Alshaer; Mohammad A Ismail; Ezaldeen Esawi; Baraa Qaqish; Abeer Al Bawab; Said I Ismail
Journal:  Molecules       Date:  2019-12-18       Impact factor: 4.411

8.  Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight.

Authors:  Claudia Riccardi; Albert Meyer; Jean-Jacques Vasseur; Domenico Cavasso; Irene Russo Krauss; Luigi Paduano; François Morvan; Daniela Montesarchio
Journal:  Int J Mol Sci       Date:  2020-05-29       Impact factor: 5.923
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.