Literature DB >> 3086004

Acute tolerance to diazepam induced by benzodiazepines.

P T Wong, Y L Yoong, M C Gwee.   

Abstract

It was observed that the effectiveness of diazepam in causing sleep, as defined by the loss of righting reflex, was significantly decreased after a single exposure to either diazepam or lorazepam. RO 15-1788, a benzodiazepine antagonist, in contrast did not induce tolerance to diazepam. The mechanism for this acute tolerance is unclear. The rapidity in its development may exclude metabolic tolerance while alterations in brain sensitivity to diazepam remain a possibility.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3086004     DOI： 10.1111/j.1440-1681.1986.tb00309.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  7 in total

1.  Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models.

Authors:  M Bourin; M Hascoet; B Mansouri; M C Colombel; J Bradwejn
Journal:  J Psychiatry Neurosci       Date:  1992-06       Impact factor: 6.186

2.  Selective breeding of mice for differential sensitivity to diazepam.

Authors:  Y L Yoong; P T Wong
Journal:  Behav Genet       Date:  1988-03       Impact factor: 2.805

3.  Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study.

Authors:  Erika Timby; Torbjörn Bäckström; Sigrid Nyberg; Hans Stenlund; Anna-Carin N Wihlbäck; Marie Bixo
Journal:  Psychopharmacology (Berl)       Date:  2016-03-10       Impact factor: 4.530

Review 4.  Tolerance to allopregnanolone with focus on the GABA-A receptor.

Authors:  Sahruh Turkmen; Torbjorn Backstrom; Goran Wahlstrom; Lotta Andreen; Inga-Maj Johansson
Journal:  Br J Pharmacol       Date:  2011-01       Impact factor: 8.739

5.  Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition.

Authors:  Tija C Jacob; Guido Michels; Liliya Silayeva; Julia Haydon; Francesca Succol; Stephen J Moss
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-22       Impact factor: 11.205

6.  Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure.

Authors:  J Dingemanse; F A Sollie; D D Breimer; M Danhof
Journal:  J Pharmacokinet Biopharm       Date:  1988-04

7.  Development of acute tolerance after oral doses of diazepam and flunitrazepam.

Authors:  J Ingum; R Bjørklund; R Volden; J Mørland
Journal:  Psychopharmacology (Berl)       Date:  1994-01       Impact factor: 4.530
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.