Hamouda Abassi1, Arthur Gavotto2, Marie Christine Picot3, Helena Bertet3, Stefan Matecki4, Sophie Guillaumont5, Stephane Moniotte6, Pascal Auquier7, Johan Moreau2, Pascal Amedro8. 1. Paediatric and Congenital Cardiology Department, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France; Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France. 2. Paediatric and Congenital Cardiology Department, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France. 3. Epidemiology Department, Montpellier University Hospital, Clinical Investigation Centre, INSERM-CIC 1411, University of Montpellier, Montpellier, France. 4. PhyMedExp, University of Montpellier, INSERM, CNRS, France. 5. Paediatric and Congenital Cardiology Department, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France; Paediatric Cardiology and Rehabilitation Unit, St-Pierre Institute, Palavas-Les-Flots, France. 6. Paediatric and Congenital Cardiology Department, St-Luc University Hospital, Brussels, Belgium. 7. Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France. 8. Paediatric and Congenital Cardiology Department, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France; Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France; PhyMedExp, University of Montpellier, INSERM, CNRS, France. Electronic address: p-amedro@chu-montpellier.fr.
Abstract
BACKGROUND: Impaired pulmonary function is an independent predictor of mortality in adult congenital heart disease (CHD), but has been scarcely studied in the paediatric CHD population. AIMS: To compare the pulmonary function of children with CHD to healthy controls, and evaluate its association with clinical outcomes, exercise capacity, and quality of life. METHODS: Cross-sectional multicentre study among 834 children (555 CHD and 279 control subjects) who underwent a complete spirometry and a cardiopulmonary exercise test (CPET). The 5th centile (Z-score = -1.64) was used to define the lower limit of normal. The association of clinical and CPET variables with spirometry was studied using a multivariate analysis. Children and their parents filled in the Kidscreen health-related quality of life questionnaire. RESULTS: Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) Z-scores values were lower in children with CHD than controls (-0.4 ± 1.5 vs. 0.4 ± 1.3, P < 0.001 and -0.5 ± 1.4 vs. 0.4 ± 1.2, P < 0.001, respectively), without any obstructive airway disorder. Restrictive pattern was more frequent in CHD patients than in controls (20% vs. 4%, P < 0.0001). FVC Z-scores were predominantly impaired in complex CHD, such as heterotaxy (-1.1 ± 0.6), single ventricle (-1.0 ± 0.2), and complex anomalies of the ventricular outflow tracts (-0.9 ± 0.1). In multivariate analysis, FVC was associated with age, body mass index, peak oxygen uptake, genetic anomalies, the number of cardiac surgery and cardiac catheter procedures. FVC and FEV1 correlated with self and proxy-related quality of life scores. CONCLUSION: These results suggest that pulmonary function should be monitored early in life, from childhood, in the CHD population. TRIAL REGISTRATION NUMBER: NCT01202916, post-results.
BACKGROUND:Impaired pulmonary function is an independent predictor of mortality in adult congenital heart disease (CHD), but has been scarcely studied in the paediatric CHD population. AIMS: To compare the pulmonary function of children with CHD to healthy controls, and evaluate its association with clinical outcomes, exercise capacity, and quality of life. METHODS: Cross-sectional multicentre study among 834 children (555 CHD and 279 control subjects) who underwent a complete spirometry and a cardiopulmonary exercise test (CPET). The 5th centile (Z-score = -1.64) was used to define the lower limit of normal. The association of clinical and CPET variables with spirometry was studied using a multivariate analysis. Children and their parents filled in the Kidscreen health-related quality of life questionnaire. RESULTS: Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) Z-scores values were lower in children with CHD than controls (-0.4 ± 1.5 vs. 0.4 ± 1.3, P < 0.001 and -0.5 ± 1.4 vs. 0.4 ± 1.2, P < 0.001, respectively), without any obstructive airway disorder. Restrictive pattern was more frequent in CHD patients than in controls (20% vs. 4%, P < 0.0001). FVC Z-scores were predominantly impaired in complex CHD, such as heterotaxy (-1.1 ± 0.6), single ventricle (-1.0 ± 0.2), and complex anomalies of the ventricular outflow tracts (-0.9 ± 0.1). In multivariate analysis, FVC was associated with age, body mass index, peak oxygen uptake, genetic anomalies, the number of cardiac surgery and cardiac catheter procedures. FVC and FEV1 correlated with self and proxy-related quality of life scores. CONCLUSION: These results suggest that pulmonary function should be monitored early in life, from childhood, in the CHD population. TRIAL REGISTRATION NUMBER: NCT01202916, post-results.
Authors: Hamouda Abassi; Helena Huguet; Marie-Christine Picot; Marie Vincenti; Sophie Guillaumont; Annie Auer; Oscar Werner; Gregoire De La Villeon; Kathleen Lavastre; Arthur Gavotto; Pascal Auquier; Pascal Amedro Journal: Health Qual Life Outcomes Date: 2020-11-12 Impact factor: 3.186
Authors: Oscar Werner; Charlene Bredy; Kathleen Lavastre; Sophie Guillaumont; Gregoire De La Villeon; Marie Vincenti; Cristelle Gerl; Yves Dulac; Nathalie Souletie; Philippe Acar; Laurence Pages; Marie-Christine Picot; Gerard Bourrel; Agnes Oude Engberink; Elodie Million; Hamouda Abassi; Pascal Amedro Journal: Health Qual Life Outcomes Date: 2021-01-19 Impact factor: 3.186
Authors: Pascal Amedro; Oscar Werner; Hamouda Abassi; Aymeric Boisson; Luc Souilla; Sophie Guillaumont; Johanna Calderon; Anne Requirand; Marie Vincenti; Victor Pommier; Stefan Matecki; Gregoire De La Villeon; Kathleen Lavastre; Alain Lacampagne; Marie-Christine Picot; Constance Beyler; Christophe Delclaux; Yves Dulac; Aitor Guitarte; Philippe Charron; Isabelle Denjoy-Urbain; Vincent Probst; Alban-Elouen Baruteau; Philippe Chevalier; Sylvie Di Filippo; Jean-Benoit Thambo; Damien Bonnet; Jean-Luc Pasquie Journal: Health Qual Life Outcomes Date: 2021-07-28 Impact factor: 3.186