Jennifer Yan1, Ajay Kevat2, Elena Martinez3, Nicky Teese4, Kareena Johnson5, Sarath Ranganathan6, Jo Harrison7, John Massie8, Andrew Daley9. 1. Department of Microbiology, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Infection Prevention and Control, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia. Electronic address: yan.jen@gmail.com. 2. Department of Respiratory Medicine, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, Victoria, Australia. Electronic address: ajaykevat@gmail.com. 3. Institute for Clinical Pathology and Medical Research, Centre for Infectious Diseases and Microbiology, Level 3, ICPMR Building, Westmead Hospital, Westmead, NSW, Australia. Electronic address: maria.martinezdiaz@sydney.edu.au. 4. Department of Microbiology, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia. Electronic address: nicky.teese@gmail.com. 5. Department of Infection Prevention and Control, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia. Electronic address: kareena.johnson@rch.org.au. 6. Department of Respiratory Medicine, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Victoria, Australia. Electronic address: sarath.ranganathan@rch.org.au. 7. Department of Respiratory Medicine, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Victoria, Australia. Electronic address: jo.harrison@rch.org.au. 8. Department of Respiratory Medicine, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Victoria, Australia. Electronic address: john.massie@rch.org.au. 9. Department of Microbiology, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Infection Prevention and Control, Royal Children's Hospital, 50 Flemington Rd, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Victoria, Australia. Electronic address: andrew.daley@rch.org.au.
Abstract
BACKGROUND: Mycobacterium abscessus is an emerging pathogen in cystic fibrosis (CF) lung disease. Hospital transmission of M. abscessus has been described. This paper details the investigation into possible cross-transmission of M. abscessus locally at our paediatric hospital CF centre, and the subsequent infection control response. METHODS: Whole genome sequencing (WGS) of M. abscessus respiratory isolates with epidemiological linkage analysis using hospital electronic medical records. RESULTS: 6.7% (22/328) of CF patients had M. abscessus isolated from respiratory specimens. WGS revealed a cluster of three patients with genomically related isolates that differed by <7 single nucleotide polymorphisms (SNPs), suggesting a shared recent ancestor and probable cross-transmission. Epidemiological investigation revealed multiple potential crossovers between patients with genomically similar M. abscessus isolates. CONCLUSIONS: Cross-infection of NTM occurs in CF hospital patients. Hospital infection control practices should be upgraded to reflect this. Consensus is needed between centres.
BACKGROUND:Mycobacterium abscessus is an emerging pathogen in cystic fibrosis (CF) lung disease. Hospital transmission of M. abscessus has been described. This paper details the investigation into possible cross-transmission of M. abscessus locally at our paediatric hospital CF centre, and the subsequent infection control response. METHODS: Whole genome sequencing (WGS) of M. abscessus respiratory isolates with epidemiological linkage analysis using hospital electronic medical records. RESULTS: 6.7% (22/328) of CFpatients had M. abscessus isolated from respiratory specimens. WGS revealed a cluster of three patients with genomically related isolates that differed by <7 single nucleotide polymorphisms (SNPs), suggesting a shared recent ancestor and probable cross-transmission. Epidemiological investigation revealed multiple potential crossovers between patients with genomically similar M. abscessus isolates. CONCLUSIONS:Cross-infection of NTM occurs in CF hospital patients. Hospital infection control practices should be upgraded to reflect this. Consensus is needed between centres.
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