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Literature DB >> 30853109

ABHD6: Its Place in Endocannabinoid Signaling and Beyond.

Jessica K Cao¹, Joshua Kaplan¹, Nephi Stella².

Abstract

The endocannabinoid (eCB) signaling system modulates neurotransmission and inflammation, among other physiological functions. Its newest member, α/β-hydrolase domain-containing 6 (ABHD6), has emerged as a promising therapeutic target to treat several devastating diseases, including epilepsy. Here, we review the molecular mechanisms that mediate and control eCB signaling and, within it, the specific role of ABHD6. We also discuss how ABHD6 controls the abundance of additional lipids and the trafficking of ionotropic receptors to plasma membranes. We finish with several unexplored questions regarding this novel enzyme. Our current understanding of the molecular mechanism and biological function of ABHD6 provides a strong foundation for the development of small-molecule therapeutics to treat devastating diseases.

Entities: CellLine Chemical Disease Gene Species

Keywords: ABHD6; endocannabinoids; enzyme; epilepsy; neuroinflammation; neurons

Mesh：

Substances：

Year: 2019 PMID： 30853109 PMCID： PMC6445269 DOI： 10.1016/j.tips.2019.02.002

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

82 in total

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Journal: J Neurotrauma Date: 2013-04-05 Impact factor: 5.269

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16 in total

1. ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB₁ Receptors.

Authors: Liting Deng; Katie Viray; Simar Singh; Ben Cravatt; Nephi Stella
Journal: Cannabis Cannabinoid Res Date: 2021-10-27

2. In situ identification of cellular drug targets in mammalian tissue.

Authors: Zhengyuan Pang; Michael A Schafroth; Daisuke Ogasawara; Yu Wang; Victoria Nudell; Neeraj K Lal; Dong Yang; Kristina Wang; Dylan M Herbst; Jacquelyn Ha; Carlos Guijas; Jacqueline L Blankman; Benjamin F Cravatt; Li Ye
Journal: Cell Date: 2022-04-27 Impact factor: 66.850

Review 3. Druggable Targets in Endocannabinoid Signaling.

Authors: Ann M Gregus; Matthew W Buczynski
Journal: Adv Exp Med Biol Date: 2020 Impact factor: 2.622

Review 4. Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.

Authors: Lu Hou; Jian Rong; Ahmed Haider; Daisuke Ogasawara; Cassis Varlow; Michael A Schafroth; Linjing Mu; Jiefeng Gan; Hao Xu; Christopher J Fowler; Ming-Rong Zhang; Neil Vasdev; Simon Ametamey; Benjamin F Cravatt; Lu Wang; Steven H Liang
Journal: J Med Chem Date: 2020-12-30 Impact factor: 7.446

5. Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells.

Authors: Annelot C M van Esbroeck; Vasudev Kantae; Xinyu Di; Tom van der Wel; Hans den Dulk; Anna F Stevens; Simar Singh; Alexander T Bakker; Bogdan I Florea; Nephi Stella; Herman S Overkleeft; Thomas Hankemeier; Mario van der Stelt
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Authors: R Cooray; V Gupta; C Suphioglu
Journal: Mol Neurobiol Date: 2020-08-19 Impact factor: 5.590