| Literature DB >> 30852803 |
Lingling Cui1,2, Fei Wang1,3,4, Miao Chang1,4, Zhiyang Yin3,4, Guoguang Fan1, Yanzhuo Song3,4, Yange Wei3,4, Yixiao Xu3,4, Yifan Zhang3,4, Yanqing Tang5,6,7, Xiaohong Gong8, Ke Xu9.
Abstract
ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Here, we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants. Amplitudes of low-frequency fluctuations (ALFFs) were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680. The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 × COMT rs4680 interaction, manifesting as a U-shaped modulation, presumably by dopamine signaling. Significant main effects were also found. These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT, and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.Entities:
Keywords: Amplitudes of low-frequency fluctuations; Catechol-O-methyltransferase; Zinc finger protein 804A; fMRI
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Year: 2019 PMID： 30852803 PMCID： PMC6616604 DOI： 10.1007/s12264-019-00357-w
Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203