Yurdaer Dönmez1, Atilla Bulut2. 1. Department of Cardiology, Adana Health Practices and Research Centre, University of Health Sciences, Adana, Turkey. yurdaerd@gmail.com. 2. Department of Cardiology, Adana Health Practices and Research Centre, University of Health Sciences, Adana, Turkey.
Abstract
PURPOSE: Increased epicardial fat thickness (EFT) is accepted as a risk factfcardiovascular diseases in some studies. There are conflicting results about the relation between plasma low-density lipoprotein cholesterol (LDL-C) level and EFT. As well, the relation between EFT and familial hypercholesterolemia is not clearly documented in the literature. Our aim was to investigate EFT in familial hypercholesterolemia patients and to determine which parameters were related to EFT increase. METHODS: A total of 150 subjects enrolled in our study. Subjects were separated into two groups: 75 hypercholesterolemia patients (16 men, mean age 52.8 ± 7.4 years) and 75 familial hypercholesterolemia patients (26 men, mean age 50.7 ± 9.2 years). Medical history assessments and complete physical examinations were done. Routine laboratory tests and echocardiographic measurements were performed. RESULTS: Coronary artery disease frequency was significantly higher in the familial hypercholesterolemia group (p < 0.001). This group had significantly higher TC and LDL-C levels than the hypercholesterolemia group (p < 0.05 for all). EFT values were higher in the familial hypercholesterolemia group, and were significantly different than in the other group (p < 0.001). LDL-C was found to be independently related to EFT in the linear regression analysis. CONCLUSIONS: Epicardial fat thickness increased in the familial hypercholesterolemia patients. In addition, LDL-C levels were significantly crelated with increased EFT.
PURPOSE: Increased epicardial fat thickness (EFT) is accepted as a risk factfcardiovascular diseases in some studies. There are conflicting results about the relation between plasma low-density lipoprotein cholesterol (LDL-C) level and EFT. As well, the relation between EFT and familial hypercholesterolemia is not clearly documented in the literature. Our aim was to investigate EFT in familial hypercholesterolemiapatients and to determine which parameters were related to EFT increase. METHODS: A total of 150 subjects enrolled in our study. Subjects were separated into two groups: 75 hypercholesterolemiapatients (16 men, mean age 52.8 ± 7.4 years) and 75 familial hypercholesterolemiapatients (26 men, mean age 50.7 ± 9.2 years). Medical history assessments and complete physical examinations were done. Routine laboratory tests and echocardiographic measurements were performed. RESULTS:Coronary artery disease frequency was significantly higher in the familial hypercholesterolemia group (p < 0.001). This group had significantly higher TC and LDL-C levels than the hypercholesterolemia group (p < 0.05 for all). EFT values were higher in the familial hypercholesterolemia group, and were significantly different than in the other group (p < 0.001). LDL-C was found to be independently related to EFT in the linear regression analysis. CONCLUSIONS: Epicardial fat thickness increased in the familial hypercholesterolemiapatients. In addition, LDL-C levels were significantly crelated with increased EFT.
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