| Literature DB >> 30852181 |
Cecilie Ammitzbøll1, Lars Börnsen2, Eva Rosa Petersen2, Annette Bang Oturai2, Helle Bach Søndergaard2, Philippe Grandjean3, Finn Sellebjerg2.
Abstract
Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.Entities:
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Year: 2019 PMID： 30852181 PMCID： PMC6461219 DOI： 10.1016/j.jneuroim.2019.03.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478