Literature DB >> 30852141

Taking SCLC on a Bad LSD(1) Trip One NOTCH Further.

Jun Kim1, Julien Sage2.   

Abstract

Small cell lung cancer (SCLC) is an aggressive form of lung cancer for which therapeutic options are very limited. A new study (Augert et al. Sci. Signal. 2019;12:eaau2922) shows that inhibition of the LSD1 demethylase can induce derepression of NOTCH receptor genes and subsequent activation of the NOTCH pathway, potently suppressing the growth of SCLC.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ASCL1; LSD1; NOTCH; SCLC; epigenetics; neuroendocrine

Mesh：

Substances：

Year:  2019        PMID： 30852141      PMCID： PMC6511648          DOI： 10.1016/j.molmed.2019.02.009

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

Review 1.  Notch in lung development and lung cancer.

Authors:  Brendan J Collins; Wolfram Kleeberger; Douglas W Ball
Journal:  Semin Cancer Biol       Date:  2004-10       Impact factor: 15.707

2.  ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Authors:  Alexander Augustyn; Mark Borromeo; Tao Wang; Junya Fujimoto; Chunli Shao; Patrick D Dospoy; Victoria Lee; Christopher Tan; James P Sullivan; Jill E Larsen; Luc Girard; Carmen Behrens; Ignacio I Wistuba; Yang Xie; Melanie H Cobb; Adi F Gazdar; Jane E Johnson; John D Minna
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-29       Impact factor: 11.205

Review 3.  2017-2018 Scientific Advances in Thoracic Oncology: Small Cell Lung Cancer.

Authors:  Stefan Zimmerman; Arundhati Das; Shuhang Wang; Ricklie Julian; Leena Gandhi; Juergen Wolf
Journal:  J Thorac Oncol       Date:  2019-02-11       Impact factor: 15.609

4.  Comprehensive genomic profiles of small cell lung cancer.

Authors:  Julie George; Jing Shan Lim; Se Jin Jang; Yupeng Cun; Luka Ozretić; Gu Kong; Frauke Leenders; Xin Lu; Lynnette Fernández-Cuesta; Graziella Bosco; Christian Müller; Ilona Dahmen; Nadine S Jahchan; Kwon-Sik Park; Dian Yang; Anthony N Karnezis; Dedeepya Vaka; Angela Torres; Maia Segura Wang; Jan O Korbel; Roopika Menon; Sung-Min Chun; Deokhoon Kim; Matt Wilkerson; Neil Hayes; David Engelmann; Brigitte Pützer; Marc Bos; Sebastian Michels; Ignacija Vlasic; Danila Seidel; Berit Pinther; Philipp Schaub; Christian Becker; Janine Altmüller; Jun Yokota; Takashi Kohno; Reika Iwakawa; Koji Tsuta; Masayuki Noguchi; Thomas Muley; Hans Hoffmann; Philipp A Schnabel; Iver Petersen; Yuan Chen; Alex Soltermann; Verena Tischler; Chang-min Choi; Yong-Hee Kim; Pierre P Massion; Yong Zou; Dragana Jovanovic; Milica Kontic; Gavin M Wright; Prudence A Russell; Benjamin Solomon; Ina Koch; Michael Lindner; Lucia A Muscarella; Annamaria la Torre; John K Field; Marko Jakopovic; Jelena Knezevic; Esmeralda Castaños-Vélez; Luca Roz; Ugo Pastorino; Odd-Terje Brustugun; Marius Lund-Iversen; Erik Thunnissen; Jens Köhler; Martin Schuler; Johan Botling; Martin Sandelin; Montserrat Sanchez-Cespedes; Helga B Salvesen; Viktor Achter; Ulrich Lang; Magdalena Bogus; Peter M Schneider; Thomas Zander; Sascha Ansén; Michael Hallek; Jürgen Wolf; Martin Vingron; Yasushi Yatabe; William D Travis; Peter Nürnberg; Christian Reinhardt; Sven Perner; Lukas Heukamp; Reinhard Büttner; Stefan A Haas; Elisabeth Brambilla; Martin Peifer; Julien Sage; Roman K Thomas
Journal:  Nature       Date:  2015-07-13       Impact factor: 49.962

5.  Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.

Authors:  Arnaud Augert; Emily Eastwood; Ali H Ibrahim; Nan Wu; Eli Grunblatt; Ryan Basom; Denny Liggitt; Keith D Eaton; Renato Martins; John T Poirier; Charles M Rudin; Francesca Milletti; Wei-Yi Cheng; Fiona Mack; David MacPherson
Journal:  Sci Signal       Date:  2019-02-05       Impact factor: 8.192

Review 6.  Notch signalling in context.

Authors:  Sarah J Bray
Journal:  Nat Rev Mol Cell Biol       Date:  2016-08-10       Impact factor: 94.444

Review 7.  LSD1: biologic roles and therapeutic targeting.

Authors:  Alba Maiques-Diaz; Tim Cp Somervaille
Journal:  Epigenomics       Date:  2016-08-01       Impact factor: 4.778

8.  Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.

Authors:  Jing Shan Lim; Alvaro Ibaseta; Marcus M Fischer; Belinda Cancilla; Gilbert O'Young; Sandra Cristea; Vincent C Luca; Dian Yang; Nadine S Jahchan; Cécile Hamard; Martine Antoine; Marie Wislez; Christina Kong; Jennifer Cain; Yu-Wang Liu; Ann M Kapoun; K Christopher Garcia; Timothy Hoey; Christopher L Murriel; Julien Sage
Journal:  Nature       Date:  2017-05-10       Impact factor: 49.962

9.  Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Authors:  Julie George; Vonn Walter; Martin Peifer; Ludmil B Alexandrov; Danila Seidel; Frauke Leenders; Lukas Maas; Christian Müller; Ilona Dahmen; Tiffany M Delhomme; Maude Ardin; Noemie Leblay; Graham Byrnes; Ruping Sun; Aurélien De Reynies; Anne McLeer-Florin; Graziella Bosco; Florian Malchers; Roopika Menon; Janine Altmüller; Christian Becker; Peter Nürnberg; Viktor Achter; Ulrich Lang; Peter M Schneider; Magdalena Bogus; Matthew G Soloway; Matthew D Wilkerson; Yupeng Cun; James D McKay; Denis Moro-Sibilot; Christian G Brambilla; Sylvie Lantuejoul; Nicolas Lemaitre; Alex Soltermann; Walter Weder; Verena Tischler; Odd Terje Brustugun; Marius Lund-Iversen; Åslaug Helland; Steinar Solberg; Sascha Ansén; Gavin Wright; Benjamin Solomon; Luca Roz; Ugo Pastorino; Iver Petersen; Joachim H Clement; Jörg Sänger; Jürgen Wolf; Martin Vingron; Thomas Zander; Sven Perner; William D Travis; Stefan A Haas; Magali Olivier; Matthieu Foll; Reinhard Büttner; David Neil Hayes; Elisabeth Brambilla; Lynnette Fernandez-Cuesta; Roman K Thomas
Journal:  Nat Commun       Date:  2018-03-13       Impact factor: 14.919

10.  Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.

Authors:  Huanhuan Joyce Chen; Asaf Poran; Arun M Unni; Sarah Xuelian Huang; Olivier Elemento; Hans-Willem Snoeck; Harold Varmus
Journal:  J Exp Med       Date:  2019-02-08       Impact factor: 14.307
  10 in total

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