Literature DB >> 30852140

Cheating Death: New Molecules Block BAX.

Loren D Walensky1.   

Abstract

BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al.https://doi.org/10.1038/s41589-018-0223-0) reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologic approach to blocking unwanted cell death in human disease.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  BAX; BCL-2 family; apoptosis; inhibitor; small molecule

Mesh：

Substances：

Year:  2019        PMID： 30852140      PMCID： PMC7255386          DOI： 10.1016/j.molmed.2019.02.008

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  Structure of Bax: coregulation of dimer formation and intracellular localization.

Authors:  M Suzuki; R J Youle; N Tjandra
Journal:  Cell       Date:  2000-11-10       Impact factor: 41.582

2.  3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.

Authors:  Agnes Bombrun; Patrick Gerber; Giulio Casi; Olivier Terradillos; Bruno Antonsson; Serge Halazy
Journal:  J Med Chem       Date:  2003-10-09       Impact factor: 7.446

3.  BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Authors:  Evripidis Gavathiotis; Denis E Reyna; Marguerite L Davis; Gregory H Bird; Loren D Walensky
Journal:  Mol Cell       Date:  2010-11-12       Impact factor: 17.970

4.  Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

Authors:  M Sattler; H Liang; D Nettesheim; R P Meadows; J E Harlan; M Eberstadt; H S Yoon; S B Shuker; B S Chang; A J Minn; C B Thompson; S W Fesik
Journal:  Science       Date:  1997-02-14       Impact factor: 47.728

5.  Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.

Authors:  Junhe Ma; Frank Edlich; Guillermo A Bermejo; Kristi L Norris; Richard J Youle; Nico Tjandra
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-03       Impact factor: 11.205

6.  Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Authors:  Lauren A Barclay; Thomas E Wales; Thomas P Garner; Franziska Wachter; Susan Lee; Rachel M Guerra; Michelle L Stewart; Craig R Braun; Gregory H Bird; Evripidis Gavathiotis; John R Engen; Loren D Walensky
Journal:  Mol Cell       Date:  2015-02-12       Impact factor: 17.970

7.  Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

Authors:  Z N Oltvai; C L Milliman; S J Korsmeyer
Journal:  Cell       Date:  1993-08-27       Impact factor: 41.582

Review 8.  BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.

Authors:  Loren D Walensky; Evripidis Gavathiotis
Journal:  Trends Biochem Sci       Date:  2011-10-04       Impact factor: 13.807

9.  An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Authors:  Thomas P Garner; Denis E Reyna; Amit Priyadarshi; Hui-Chen Chen; Sheng Li; Yang Wu; Yogesh Tengarai Ganesan; Vladimir N Malashkevich; Emily H Cheng; Evripidis Gavathiotis
Journal:  Mol Cell       Date:  2016-07-14       Impact factor: 17.970

10.  BAX activation is initiated at a novel interaction site.

Authors:  Evripidis Gavathiotis; Motoshi Suzuki; Marguerite L Davis; Kenneth Pitter; Gregory H Bird; Samuel G Katz; Ho-Chou Tu; Hyungjin Kim; Emily H-Y Cheng; Nico Tjandra; Loren D Walensky
Journal:  Nature       Date:  2008-10-23       Impact factor: 49.962
  10 in total

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