Alessandro Boccanelli1, Gian Francesco Mureddu2, Giulia Cesaroni3, Francesco Prati2, Fabio Rangoni4, Nera Agabiti3, Marina Davoli3, Angela Beatrice Scardovi5, Roberto Latini6. 1. Casa di Cura Quisisana, Rome, Italy. Electronic address: boccanelli.alessandro@gmail.com. 2. Azienda Ospedaliera S. Giovanni-Addolorata, Rome, Italy. 3. Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy. 4. Cardioline Spa, Trento, Italy. 5. Ospedale Santo Spirito, Rome, Italy. 6. Department of Cardiovascular Research, IRCCSS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Abstract
AIMS: The principal aims of this prospective multicentre study were to relate the presence of interatrial block (IAB) with a late occurrence of atrial fibrillation (AF) and to demonstrate the independence of the IAB effect on risk of AF from structural cardiac alterations. METHODS: This prospective study was the follow-up of subjects included in the PREDICTOR cross-sectional population-based study. Subjects were divided into groups according to IAB status. Socio-demographic and health characteristic were collected during enrolment in the PREDICTOR along with ECGs, echocardiograms and NT-proBNP dosages. Follow up was performed on administrative data. The mean time of follow up was 6.6 years. RESULTS: 1626 subjects were included in the analysis. Four hundred-fifteen subjects out of 1626 (25.5%) had IAB. The survival analysis suggests an association between IAB alone and AF (HR = 1.50, p = 0.058) and, in normal-weight subjects, IAB strongly predicted AF indicating more than triple the risk (HR = 3.05; p = 0.002 95% CI: 1.51-6.18). The association seems to be independent of possible confounders such as history of IHD, left ventricular hypertrophy, CHA2DS2-VASc, left atrial dimension, or NT-proBNP dosage. CONCLUSION: Our analysis suggests that IAB is an electric condition that can increase the risk of AF independently of any structural cardiac alterations, at least in normal-weight subjects.
AIMS: The principal aims of this prospective multicentre study were to relate the presence of interatrial block (IAB) with a late occurrence of atrial fibrillation (AF) and to demonstrate the independence of the IAB effect on risk of AF from structural cardiac alterations. METHODS: This prospective study was the follow-up of subjects included in the PREDICTOR cross-sectional population-based study. Subjects were divided into groups according to IAB status. Socio-demographic and health characteristic were collected during enrolment in the PREDICTOR along with ECGs, echocardiograms and NT-proBNP dosages. Follow up was performed on administrative data. The mean time of follow up was 6.6 years. RESULTS: 1626 subjects were included in the analysis. Four hundred-fifteen subjects out of 1626 (25.5%) had IAB. The survival analysis suggests an association between IAB alone and AF (HR = 1.50, p = 0.058) and, in normal-weight subjects, IAB strongly predicted AF indicating more than triple the risk (HR = 3.05; p = 0.002 95% CI: 1.51-6.18). The association seems to be independent of possible confounders such as history of IHD, left ventricular hypertrophy, CHA2DS2-VASc, left atrial dimension, or NT-proBNP dosage. CONCLUSION: Our analysis suggests that IAB is an electric condition that can increase the risk of AF independently of any structural cardiac alterations, at least in normal-weight subjects.
Authors: Raimundo Carmona Puerta; Elizabeth Lorenzo Martínez; Magda Alina Rabassa López-Calleja; Gustavo Padrón Peña; Yaniel Castro Torres; Juan Miguel Cruz Elizundia; Fernando Rodríguez González; Luis Ángel García Vázquez; Elibet Chávez González Journal: Med Princ Pract Date: 2021-07-07 Impact factor: 1.927