| Literature DB >> 30851419 |
Bing-Qi Li1, Zhi-Yong Liang2, Samuel Seery3, Qiao-Fei Liu4, Lei You5, Tai-Ping Zhang6, Jun-Chao Guo7, Yu-Pei Zhao8.
Abstract
WT1 associated protein (WTAP), playing an important role in several malignancies owing to its complex function in transcriptional and post-transcriptional regulation, is an independent prognostic indicator for pancreatic cancer (PC). However, its specific role and underlying mechanism in PC remain unclear. In the present study, we found that WTAP could promote migration/invasion and suppress chemo-sensitivity to gemcitabine in PC. Further mechanical investigation revealed that WTAP could bind to and stabilize Fak mRNA which in turn activated the Fak-PI3K-AKT and Fak-Src-GRB2-Erk1/2 signaling pathways. In addition, GSK2256098, a specific Fak inhibitor, could reverse WTAP-mediated chemo-resistance to gemcitabine and metastasis in PC. Taken together, Fak inhibitor might be a promising therapeutic option for PC patients with WTAP overexpression.Entities:
Keywords: Chemo-sensitivity; Fak; Migration/invasion; PC; WTAP
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Year: 2019 PMID： 30851419 DOI： 10.1016/j.canlet.2019.02.043
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679