Metabolic reprogramming links chronic intestinal inflammation and the oncogenic transformation in colorectal tumorigenesis.

The causal connections between chronic inflammation and tumorigenesis are well established and supported by a great deal of evidence and research results over recent decades. Still, many mysteries remain in our understanding of tumor metabolism, not to mention inflammatory-oncogenic transformation. In this review, we examined the Warburg effect and the process of inflammation during tumorigenesis and attempted to extend the knowledge about metabolic reprogramming. This review may establish a useful conceptual framework for understanding the complex pathophysiological process of inflammatory-oncogenic transformation from the metabolic perspective.