OBJECTIVE: Sleep disturbance may be involved in symptom progression across multiple domains of psychopathology and could represent a target for treatment development in youth. Our objective was to identify sleep patterns that longitudinally change in conjunction with psychiatric symptom severity in at-risk youth. METHOD: The study included 484 Pittsburgh Bipolar Offspring Study (BIOS) youth with at least 2 sleep assessments occurring between 10 and 18 years of age: 267 offspring of parents with bipolar I or II disorder and 217 community comparison offspring. Assessments occurred approximately every 2 years (mean number of assessments, 2.8 ± 0.8; mean follow-up duration, 3.8 ± 1.6 years). Offspring had a range of psychiatric diagnoses at baseline. Multivariate lasso regression was implemented to select offspring-reported sleep patterns associated with changes in five psychiatric symptom measures from baseline through last follow-up (mania, depression, mood lability, anxiety, inattention/externalizing). Analyses accounted for parent psychiatric diagnoses and offspring demographics, psychiatric diagnoses, and medications. RESULTS: Follow-up duration, baseline socioeconomic status, parental history of bipolar disorder, offspring attention-deficit/hyperactivity disorder, and disruptive behavior disorder, and five sleep patterns were identified as predictors of change in all five psychiatric symptom measures. Decreasing sleep duration, later sleep timing preference, longer sleep latency, increasing nighttime awakenings, and greater sleepiness over follow-up were associated with increasing severity the five psychiatric symptom outcomes over follow-up. These 10 predictors explained 16% of the variance in longitudinal psychiatric symptom change, 33% of which was accounted for by sleep predictors. CONCLUSION: A constellation of sleep features were associated with psychiatric symptom changes in youth, and may represent viable targets for future interventions.
OBJECTIVE: Sleep disturbance may be involved in symptom progression across multiple domains of psychopathology and could represent a target for treatment development in youth. Our objective was to identify sleep patterns that longitudinally change in conjunction with psychiatric symptom severity in at-risk youth. METHOD: The study included 484 Pittsburgh Bipolar Offspring Study (BIOS) youth with at least 2 sleep assessments occurring between 10 and 18 years of age: 267 offspring of parents with bipolar I or II disorder and 217 community comparison offspring. Assessments occurred approximately every 2 years (mean number of assessments, 2.8 ± 0.8; mean follow-up duration, 3.8 ± 1.6 years). Offspring had a range of psychiatric diagnoses at baseline. Multivariate lasso regression was implemented to select offspring-reported sleep patterns associated with changes in five psychiatric symptom measures from baseline through last follow-up (mania, depression, mood lability, anxiety, inattention/externalizing). Analyses accounted for parent psychiatric diagnoses and offspring demographics, psychiatric diagnoses, and medications. RESULTS: Follow-up duration, baseline socioeconomic status, parental history of bipolar disorder, offspring attention-deficit/hyperactivity disorder, and disruptive behavior disorder, and five sleep patterns were identified as predictors of change in all five psychiatric symptom measures. Decreasing sleep duration, later sleep timing preference, longer sleep latency, increasing nighttime awakenings, and greater sleepiness over follow-up were associated with increasing severity the five psychiatric symptom outcomes over follow-up. These 10 predictors explained 16% of the variance in longitudinal psychiatric symptom change, 33% of which was accounted for by sleep predictors. CONCLUSION: A constellation of sleep features were associated with psychiatric symptom changes in youth, and may represent viable targets for future interventions.
Authors: David Axelson; Boris Birmaher; Michael Strober; Mary Kay Gill; Sylvia Valeri; Laurel Chiappetta; Neal Ryan; Henrietta Leonard; Jeffrey Hunt; Satish Iyengar; Jeffrey Bridge; Martin Keller Journal: Arch Gen Psychiatry Date: 2006-10
Authors: Amy R Wolfson; Mary A Carskadon; Christine Acebo; Ronald Seifer; Gahan Fallone; Susan E Labyak; Jennifer L Martin Journal: Sleep Date: 2003-03-15 Impact factor: 5.849
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: Michele A Bertocci; Ronald E Dahl; Douglas E Williamson; Ana-Maria Iosif; Boris Birmaher; David Axelson; Neal D Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 2005-11 Impact factor: 8.829
Authors: Boris Birmaher; David Axelson; Kelly Monk; Catherine Kalas; Benjamin Goldstein; Mary Beth Hickey; Mihaela Obreja; Mary Ehmann; Satish Iyengar; Wael Shamseddeen; David Kupfer; David Brent Journal: Arch Gen Psychiatry Date: 2009-03
Authors: Jessica C Levenson; Brian C Thoma; Jessica L Hamilton; Sophia Choukas-Bradley; Rachel H Salk Journal: Sleep Date: 2021-03-12 Impact factor: 5.849
Authors: Jessica L Hamilton; Shannon Chand; Lauren Reinhardt; Cecile D Ladouceur; Jennifer S Silk; Megan Moreno; Peter L Franzen; Lauren M Bylsma Journal: J Adolesc Date: 2020-08-06
Authors: Maria Jalbrzikowski; Rebecca A Hayes; Kathleen E Scully; Peter L Franzen; Brant P Hasler; Greg J Siegle; Daniel J Buysse; Ronald E Dahl; Erika E Forbes; Cecile D Ladouceur; Dana L McMakin; Neal D Ryan; Jennifer S Silk; Tina R Goldstein; Adriane M Soehner Journal: Sleep Date: 2021-10-11 Impact factor: 5.849
Authors: Meredith L Wallace; Nicholas Kissel; Martica H Hall; Anne Germain; Karen A Matthews; Wendy M Troxel; Peter L Franzen; Daniel J Buysse; Charles Reynolds; Kathryn A Roecklein; Heather E Gunn; Brant P Hasler; Tina R Goldstein; Dana L McMakin; Eva Szigethy; Adriane M Soehner Journal: Psychosom Med Date: 2022-01-28 Impact factor: 3.864
Authors: Elisabet Blok; M Elisabeth Koopman-Verhoeff; Daniel P Dickstein; Jared Saletin; Annemarie I Luik; Jolien Rijlaarsdam; Manon Hillegers; Desana Kocevska; Tonya White; Henning Tiemeier Journal: Child Adolesc Psychiatry Ment Health Date: 2022-02-17 Impact factor: 3.033
Authors: Carly Lupton-Smith; Elizabeth A Stuart; Emma E McGinty; Arlene T Dalcin; Gerald J Jerome; Nae-Yuh Wang; Gail L Daumit Journal: Front Psychiatry Date: 2022-02-03 Impact factor: 4.157