Literature DB >> 30850508

Let's get this pyrin started!

Emilia Liana Falcone1,2, Clare Bryant3.   

Abstract

Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest that microbiota may be able to modulate this inflammatory process which, in turn, may contribute to the maintenance of intestinal homeostasis.
© 2019 Falcone and Bryant.

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Year:  2019        PMID： 30850508      PMCID： PMC6416431          DOI： 10.1074/jbc.H119.007830

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  8 in total

1.  Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.

Authors:  Rafaz Hoque; Ahmad Farooq; Ayaz Ghani; Fred Gorelick; Wajahat Zafar Mehal
Journal:  Gastroenterology       Date:  2014-03-20       Impact factor: 22.682

Review 2.  Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.

Authors:  Tomasz Próchnicki; Eicke Latz
Journal:  Cell Metab       Date:  2017-07-05       Impact factor: 27.287

Review 3.  Inflammasomes: mechanism of assembly, regulation and signalling.

Authors:  Petr Broz; Vishva M Dixit
Journal:  Nat Rev Immunol       Date:  2016-06-13       Impact factor: 53.106

4.  Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Authors:  Deepika Sharma; Ankit Malik; Clifford S Guy; Rajendra Karki; Peter Vogel; Thirumala-Devi Kanneganti
Journal:  Gastroenterology       Date:  2017-12-02       Impact factor: 22.682

5.  Bile acid analogues are activators of pyrin inflammasome.

Authors:  Irina Alimov; Suchithra Menon; Nadire Cochran; Rob Maher; Qiong Wang; John Alford; John B Concannon; Zinger Yang; Edmund Harrington; Luis Llamas; Alicia Lindeman; Gregory Hoffman; Tim Schuhmann; Carsten Russ; John Reece-Hoyes; Stephen M Canham; Xinming Cai
Journal:  J Biol Chem       Date:  2019-01-15       Impact factor: 5.157

6.  Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

Authors:  Laurence Macia; Jian Tan; Angelica T Vieira; Katie Leach; Dragana Stanley; Suzanne Luong; Mikako Maruya; Craig Ian McKenzie; Atsushi Hijikata; Connie Wong; Lauren Binge; Alison N Thorburn; Nina Chevalier; Caroline Ang; Eliana Marino; Remy Robert; Stefan Offermanns; Mauro M Teixeira; Robert J Moore; Richard A Flavell; Sidonia Fagarasan; Charles R Mackay
Journal:  Nat Commun       Date:  2015-04-01       Impact factor: 17.694

7.  Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

Authors:  Maayan Levy; Christoph A Thaiss; David Zeevi; Lenka Dohnalová; Gili Zilberman-Schapira; Jemal Ali Mahdi; Eyal David; Alon Savidor; Tal Korem; Yonatan Herzig; Meirav Pevsner-Fischer; Hagit Shapiro; Anette Christ; Alon Harmelin; Zamir Halpern; Eicke Latz; Richard A Flavell; Ido Amit; Eran Segal; Eran Elinav
Journal:  Cell       Date:  2015-12-03       Impact factor: 41.582

8.  Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.

Authors:  Hanne Van Gorp; Pedro H V Saavedra; Nathalia M de Vasconcelos; Nina Van Opdenbosch; Lieselotte Vande Walle; Magdalena Matusiak; Giusi Prencipe; Antonella Insalaco; Filip Van Hauwermeiren; Dieter Demon; Delfien J Bogaert; Melissa Dullaers; Elfride De Baere; Tino Hochepied; Joke Dehoorne; Karim Y Vermaelen; Filomeen Haerynck; Fabrizio De Benedetti; Mohamed Lamkanfi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-22       Impact factor: 11.205
  8 in total

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