Özgül Ekmekcioglu1, Martijn Busstra2, Natalie Desiree Klass3, Fred Verzijlbergen4. 1. Nuclear Medicine Department, Sisli Etfal Education and Research Hospital, Istanbul, Turkey ozgulek@gmail.com. 2. Urology Department, Erasmus Medical Center, Rotterdam, The Netherlands. 3. Radiation Oncology Department, Bern University Hospital, Bern, Switzerland; and. 4. Radiology and Nuclear Medicine Department, Radboud University Medical Center, Nijmegen, The Netherlands.
Abstract
68Ga- and 18F-labeled prostate-specific membrane antigen (PSMA) molecules have created new opportunities for the unmet diagnostic needs in prostate cancer. The purpose of this article is to give an overview of studies that have examined the role of PSMA PET in treatment planning for prostate cancer patients with biochemical recurrence (BCR). Methods: Medline, Embase, Web of Science, Google Scholar, and Cochrane Central were searched for relevant articles. After excluding the articles that did not fulfill the required criteria, we included in this review 12 publications that reported the impact of PSMA PET on the treatment plan for prostate cancer patients with BCR. Results: All studies in our review emphasized the impact of PSMA PET images on therapy management in prostate cancer patients with BCR. Overall, the impact of PSMA PET/CT on therapy management varied between 30% and 76% among the 1,346 patients included in the review. Upstaging was reported in 32%-67% of the patients. Patients with low prostate-specific antigen values (<0.5 ng/mL) also demonstrated positive lesions, which could not have been detected by means of conventional imaging techniques. Important modifications to the original treatment plan included avoidance of systemic therapy (17%-40%) and PET-directed local therapy (in ≤60% of the patients). Conclusion: PSMA imaging demonstrated a high clinical impact in patients with BCR, with modifications to the original treatment plan occurring among half the patients. Detecting recurrence in BCR can prevent unnecessary toxicity and lead to individualized therapy.
68Ga- and 18F-labeled prostate-specific membrane antigen (PSMA) molecules have created new opportunities for the unmet diagnostic needs in prostate cancer. The purpose of this article is to give an overview of studies that have examined the role of PSMA PET in treatment planning for prostate cancerpatients with biochemical recurrence (BCR). Methods: Medline, Embase, Web of Science, Google Scholar, and Cochrane Central were searched for relevant articles. After excluding the articles that did not fulfill the required criteria, we included in this review 12 publications that reported the impact of PSMA PET on the treatment plan for prostate cancerpatients with BCR. Results: All studies in our review emphasized the impact of PSMA PET images on therapy management in prostate cancerpatients with BCR. Overall, the impact of PSMA PET/CT on therapy management varied between 30% and 76% among the 1,346 patients included in the review. Upstaging was reported in 32%-67% of the patients. Patients with low prostate-specific antigen values (<0.5 ng/mL) also demonstrated positive lesions, which could not have been detected by means of conventional imaging techniques. Important modifications to the original treatment plan included avoidance of systemic therapy (17%-40%) and PET-directed local therapy (in ≤60% of the patients). Conclusion:PSMA imaging demonstrated a high clinical impact in patients with BCR, with modifications to the original treatment plan occurring among half the patients. Detecting recurrence in BCR can prevent unnecessary toxicity and lead to individualized therapy.
Authors: F H E Staal; J Janssen; C L Brouwer; J A Langendijk; K Ng Wei Siang; E Schuit; I J de Jong; J F Verzijlbergen; R J Smeenk; S Aluwini Journal: BMC Cancer Date: 2022-04-15 Impact factor: 4.638
Authors: Jyoti Roy; Margaret E White; Falguni Basuli; Ana Christina L Opina; Karen Wong; Morgan Riba; Anita T Ton; Xiang Zhang; Keith H Jansson; Elijah Edmondson; Donna Butcher; Frank I Lin; Peter L Choyke; Kathleen Kelly; Elaine M Jagoda Journal: Mol Imaging Biol Date: 2021-04-23 Impact factor: 3.488
Authors: Patrick Bowden; Andrew W See; Kevin So; Nathan Lawrentschuk; Daniel Moon; Declan G Murphy; Ranjit Rao; Alan Crosthwaite; Dennis King; Hodo Haxhimolla; Jeremy Grummet; Paul Ruljancich; Dennis Gyomber; Adam Landau; Nicholas Campbell; Mark Frydenberg; Lloyd M L Smyth; Skye Nolan; Stella M Gwini; Dean P McKenzie Journal: World J Urol Date: 2021-06-02 Impact factor: 4.226