Literature DB >> 30849547

Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer.

Vijay S Madamsetty1, Anil Sharma1, Maria Toma2, Stefanie Samaniego2, Audrey Gallud2, Enfeng Wang1, Krishnendu Pal1, Debabrata Mukhopadhyay3, Bengt Fadeel4.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Drug delivery; Nanodiamonds; Nanomedicine; Pancreatic adenocarcinoma

Mesh：

Substances：

Year:  2019        PMID： 30849547      PMCID： PMC6588439          DOI： 10.1016/j.nano.2019.02.020

Source DB:  PubMed          Journal:  Nanomedicine        ISSN： 1549-9634            Impact factor:   5.307


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