Literature DB >> 30849361

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease.

Joel W Blanchard1, Li-Huei Tsai2.   

Abstract

Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30849361     DOI： 10.1016/j.stem.2019.02.003

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  4 in total

1.  Statins and Cognitive Impairment: Not a Culprit, Protective in Some?

Authors:  Costantino Iadecola; Neal S Parikh
Journal:  J Am Coll Cardiol       Date:  2019-11-26       Impact factor: 24.094

Review 2.  Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease.

Authors:  Mingcui Zheng; Pengwen Wang
Journal:  3 Biotech       Date:  2021-03-20       Impact factor: 2.406

Review 3.  Statins and cognition: Modifying factors and possible underlying mechanisms.

Authors:  Tahereh Jamshidnejad-Tosaramandani; Soheila Kashanian; Mohamed H Al-Sabri; Daniela Kročianová; Laura E Clemensson; Mélissa Gentreau; Helgi B Schiöth
Journal:  Front Aging Neurosci       Date:  2022-08-15       Impact factor: 5.702

4.  Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study.

Authors:  Vijay R Varma; H Büşra Lüleci; Anup M Oommen; Sudhir Varma; Chad T Blackshear; Michael E Griswold; Yang An; Jackson A Roberts; Richard O'Brien; Olga Pletnikova; Juan C Troncoso; David A Bennett; Tunahan Çakır; Cristina Legido-Quigley; Madhav Thambisetty
Journal:  NPJ Aging Mech Dis       Date:  2021-06-01
  4 in total

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