Ulrik Lausten-Thomsen1, Morten Asp Vonsild Lund2, Christine Frithioff-Bøjsøe3, Paula Louise Hedley4, Oluf Pedersen5, Torben Hansen5, Michael Christiansen6, Jens-Christian Holm7. 1. Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark. Electronic address: ulrik.lausten-thomsen@regionh.dk. 2. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. 3. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. 4. Department for Congenital Disorders, Danish National Biobank and Biomarkers, Statens Serum Institut, Copenhagen, Denmark. 5. The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. 6. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Department for Congenital Disorders, Danish National Biobank and Biomarkers, Statens Serum Institut, Copenhagen, Denmark. 7. The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Abstract
BACKGROUND: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios. METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits. RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001). CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.
BACKGROUND:Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios. METHODS: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits. RESULTS: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001). CONCLUSION: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.
Authors: Baris Akinci; Rasimcan Meral; Diana Rus; Rita Hench; Adam H Neidert; Frank DiPaola; Maria Westerhoff; Simeon I Taylor; Elif A Oral Journal: Endocrinol Diabetes Metab Case Rep Date: 2020-03-25