Literature DB >> 308492

PKU locus: genetic linkage with human amylase (Amy) loci and assignment to linkage group I.

J Kamarýt, A Mrskos, O Podhradská, V Kolcová, B Cabalska, N Duczyńska, J Borzymowska.   

Abstract

The linked alpha-amylase loci Amy 1 and Amy 2 were evaluated for their linkage relationship to the PKU locus using data collected from two (one Czech and one Polish) groups of families. The five sibships informative for Amy 1:PKU give a z score of 1.505 at theta = 0.00 and the eight sibships informative for Amy 2:PKU give a z score of 2.709 at theta = 0.00. Due to the tandem position of Amy 1 and Amy 2 loci, these data could be combined, and linkage between Amy and PKU loci established with a z score 4,214 at theta = 0.00. The practical significance of the linkage, especially for identifying PKU allele carriers, is emphasized.

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Year:  1978        PMID： 308492     DOI： 10.1007/bf00293596

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Sequential tests for the detection of linkage.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

2.  Phenylketonuria; data on 47 British families.

Authors:  T A MUNRO
Journal:  Ann Eugen       Date:  1947-10

3.  Data for the study of linkage in man; phenylketonuria and the ABO and MN loci.

Authors:  L S PENROSE
Journal:  Ann Eugen       Date:  1951-12

4.  Probable genetic linkage between human serum amylase (Amy 2 ) and Duffy blood group.

Authors:  C J Hill; S I Rowe; E W Lovrien
Journal:  Nature       Date:  1972-01-21       Impact factor: 49.962

5.  Human amylase loci: genetic linkage with the Duffy blood group locus and assignment to linkage group I.

Authors:  A D Merritt; E W Lovrien; M L Rivas; P M Conneally
Journal:  Am J Hum Genet       Date:  1973-09       Impact factor: 11.025

6.  Possible linkage between uncoiler chromosome Un 1 and amylase polymorphism Amy 2 loci.

Authors:  J Kamarýt; R Adámek; M Vrba
Journal:  Humangenetik       Date:  1971

7.  [Phenylalanine tolerance tests].

Authors:  A Mrskos; O Podhradská
Journal:  Cesk Pediatr       Date:  1970-03

8.  A linkage study of phenylketonuria.

Authors:  K Berg; L F Saugstad
Journal:  Clin Genet       Date:  1974       Impact factor: 4.438

9.  Amylase heterogeneity. Some genetik and clinical aspects.

Authors:  J Kamarýt; R Laxová
Journal:  Humangenetik       Date:  1965
  9 in total
  6 in total

1.  Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4.

Authors:  P Kuhl; K Olek; P Wardenbach; K H Grzeschik
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

2.  A maximum likelihood map of chromosome 1.

Authors:  D C Rao; B J Keats; J M Lalouel; N E Morton; S Yee
Journal:  Am J Hum Genet       Date:  1979-11       Impact factor: 11.025

3.  Regional mapping of the phenylalanine hydroxylase gene and the phenylketonuria locus in the human genome.

Authors:  A S Lidsky; M L Law; H G Morse; F T Kao; M Rabin; F H Ruddle; S L Woo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

4.  The PKU locus in man is on chromosome 12.

Authors:  A S Lidksy; K J Robson; C Thirumalachary; P E Barker; F H Ruddle; S L Woo
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

5.  The genetic linkage between the PKU locus and the loci for amylase 1, amylase 2, Fy, PGM 1, and Rh and the question of assignment of the PKU locus to chromosome no. 1.

Authors:  A Knapp; R Tintschewa; E Scheibe; E Scheibe; B Jäger; K E Biebler
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

6.  Phenylketonuria (PKU) and the single gene: an old story retold.

Authors:  R M Murphey
Journal:  Behav Genet       Date:  1983-03       Impact factor: 2.805
  6 in total

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