OBJECTIVES: To evaluate the independent association between symptom burden and physical function impairment in older adults with cancer. DESIGN: Cross-sectional. SETTING: Two university-based geriatric oncology clinics. PARTICIPANTS: Patients with cancer aged 65 years or older who underwent evaluation with geriatric assessment (GA). MEASUREMENTS: Symptom burden was measured as a summary score of severity ratings (range = 0-10) of 10 commonly reported symptoms using a Clinical Symptom Inventory (CSI). Functional impairment was defined as the presence of one or more impairments of instrumental activities of daily living (IADLs), any significant physical activity limitation on the Medical Outcomes Survey (MOS), one or more recent falls in the previous 6 months, or a Short Physical Performance Battery (SPPB) score of 9 or less. Multivariate analysis evaluated the association between symptom burden and physical function impairment, adjusting for other clinical and sociodemographic variables. RESULTS: From 2011 to 2015, 359 patients with cancer and a median age of 81 years (range = 65-95 y) consented. The mean CSI score was 23.2 ± 20.5 with an observed range of 0 to 90. Patients in the highest quartile of symptom burden (N = 91; CSI score 52 ± 13) had a higher prevalence of IADL impairment (91% vs 51%), physical activity limitation (93% vs 65%), falls (55% vs 21%), and SPPB score of 9 or less (92% vs 69%) (all P values <.01) when compared with those in the bottom quartile (N = 81; CSI score: 2 ± 2). With each unit increase in CSI score, the odds of having IADL impairment, physical activity limitations, falls, and SPPB scores of 9 or less increased by 4.8%, 4.4%, 2.9%, and 2.5%, respectively (P < .05 for all results). CONCLUSIONS: In older patients with cancer, higher symptom burden is associated with functional impairment. Future studies are warranted to evaluate if improved symptom management can improve function in older cancer patients. J Am Geriatr Soc 67:998-1004, 2019.
OBJECTIVES: To evaluate the independent association between symptom burden and physical function impairment in older adults with cancer. DESIGN: Cross-sectional. SETTING: Two university-based geriatric oncology clinics. PARTICIPANTS: Patients with cancer aged 65 years or older who underwent evaluation with geriatric assessment (GA). MEASUREMENTS: Symptom burden was measured as a summary score of severity ratings (range = 0-10) of 10 commonly reported symptoms using a Clinical Symptom Inventory (CSI). Functional impairment was defined as the presence of one or more impairments of instrumental activities of daily living (IADLs), any significant physical activity limitation on the Medical Outcomes Survey (MOS), one or more recent falls in the previous 6 months, or a Short Physical Performance Battery (SPPB) score of 9 or less. Multivariate analysis evaluated the association between symptom burden and physical function impairment, adjusting for other clinical and sociodemographic variables. RESULTS: From 2011 to 2015, 359 patients with cancer and a median age of 81 years (range = 65-95 y) consented. The mean CSI score was 23.2 ± 20.5 with an observed range of 0 to 90. Patients in the highest quartile of symptom burden (N = 91; CSI score 52 ± 13) had a higher prevalence of IADL impairment (91% vs 51%), physical activity limitation (93% vs 65%), falls (55% vs 21%), and SPPB score of 9 or less (92% vs 69%) (all P values <.01) when compared with those in the bottom quartile (N = 81; CSI score: 2 ± 2). With each unit increase in CSI score, the odds of having IADL impairment, physical activity limitations, falls, and SPPB scores of 9 or less increased by 4.8%, 4.4%, 2.9%, and 2.5%, respectively (P < .05 for all results). CONCLUSIONS: In older patients with cancer, higher symptom burden is associated with functional impairment. Future studies are warranted to evaluate if improved symptom management can improve function in older cancerpatients. J Am Geriatr Soc 67:998-1004, 2019.
Authors: Jessica L Petrick; Bryce B Reeve; Anna M Kucharska-Newton; Randi E Foraker; Elizabeth A Platz; Sally C Stearns; Xuesong Han; B Gwen Windham; Debra E Irwin Journal: J Geriatr Oncol Date: 2014-06-26 Impact factor: 3.599
Authors: David B Reuben; Teresa E Seeman; Emmett Keeler; Risa P Hayes; Lee Bowman; Ase Sewall; Susan H Hirsch; Robert B Wallace; Jack M Guralnik Journal: J Gerontol A Biol Sci Med Sci Date: 2004-10 Impact factor: 6.053
Authors: Lanell Bellury; Marjorie A Pett; Lee Ellington; Susan L Beck; Jane C Clark; Kevin D Stein Journal: Cancer Date: 2012-06-06 Impact factor: 6.860
Authors: Melisa L Wong; Steven M Paul; Judy Mastick; Christine Ritchie; Michael A Steinman; Louise C Walter; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2018-08-23 Impact factor: 3.612
Authors: Richard J Lin; Abigail G Cohen; Stacy M Stabler; Sean M Devlin; Theresa A Elko; Molly A Maloy; Beatriz Korc-Grodzicki; Koshy Alexander; Dana Kramer; Míriam Sanchez-Escamilla; Nerea Castillo Flores; Juliet N Barker; Christina Cho; Parastoo B Dahi; Boglarka Gyurkocza; Esperanza B Papadopoulos; Miguel-Angel Perales; Ioannis Politikos; Doris M Ponce; Craig S Sauter; Michael Scordo; Brian C Shaffer; Gunjan L Shah; Roni Tamari; James W Young; Ann A Jakubowski; Sergio A Giralt; Judith E Nelson Journal: J Palliat Med Date: 2020-03-27 Impact factor: 2.947
Authors: Komal P Murali; Gary Yu; John D Merriman; Allison Vorderstrasse; Amy S Kelley; Abraham A Brody Journal: Nurs Res Date: 2021 Nov-Dec 01 Impact factor: 2.381
Authors: Janice S Withycombe; Molly McFatrich; Pamela S Hinds; Antonia Bennett; Li Lin; Scott H Maurer; Nicole R Lucas; Courtney M Mann; Sharon M Castellino; Justin N Baker; Bryce B Reeve Journal: Cancer Nurs Date: 2022-02-05 Impact factor: 2.760
Authors: Nikesha Gilmore; Huiwen Xu; Lee Kehoe; Amber S Kleckner; Kiran Moorthi; Lianlian Lei; Mostafa R S Mohamed; Kah Poh Loh; Eva Culakova; Marie Flannery; Erika Ramsdale; Paul R Duberstein; Beverly Canin; Charles Kamen; Gilbert Giri; Erin Watson; Amita Patil; Adedayo A Onitilo; Brian Burnette; Michelle Janelsins; Supriya G Mohile Journal: Cancer Date: 2021-11-11 Impact factor: 6.921
Authors: Eni Shehu; Sigrid Roggendorf; André Golla; Antonia Koenig; Gabriele I Stangl; Andrea Diestelhorst; Daniel Medenwald; Dirk Vordermark; Anke Steckelberg; Heike Schmidt Journal: Cancers (Basel) Date: 2022-05-24 Impact factor: 6.575
Authors: Ryan D Nipp; Brandon Temel; Charn-Xin Fuh; Paul Kay; Sophia Landay; Daniel Lage; Esteban Franco-Garcia; Erin Scott; Erin Stevens; Terrence O'Malley; Supriya Mohile; William Dale; Lara Traeger; Ardeshir Z Hashmi; Vicki Jackson; Joseph A Greer; Areej El-Jawahri; Jennifer S Temel Journal: J Natl Compr Canc Netw Date: 2020-05 Impact factor: 11.908
Authors: Kah Poh Loh; Mostafa R Mohamed; Sindhuja Kadambi; Eva Culakova; Huiwen Xu; Allison Magnuson; Marie Flannery; Paul R Duberstein; Ronald M Epstein; Colin McHugh; Ryan D Nipp; Kelly M Trevino; Chandrika Sanapala; Bianca A Hall; Beverly Canin; Arlene A Gayle; Alison Conlin; James Bearden; Supriya G Mohile Journal: Oncologist Date: 2021-02-13 Impact factor: 5.837
Authors: Elizabeth J Siembida; Ashley Wilder Smith; Arnold L Potosky; Kristi D Graves; Roxanne E Jensen Journal: Qual Life Res Date: 2021-01-14 Impact factor: 3.440
Authors: Marie A Flannery; Eva Culakova; Beverly E Canin; Luke Peppone; Erika Ramsdale; Supriya G Mohile Journal: J Clin Oncol Date: 2021-05-27 Impact factor: 44.544