Literature DB >> 30848453

Miniaturized Checkerboard Assays to Measure Antibiotic Interactions.

Melike Cokol-Cakmak1, Murat Cokol2,3.   

Abstract

Drugs may have synergistic or antagonistic interactions when combined. Checkerboard assays, where two drugs are combined in many doses, allow sensitive measurement of drug interactions. Here, we describe a protocol to measure the pairwise interactions among three antibiotics, in duplicate, in 5 days, using only two 96-well microplates and standard laboratory equipment.

Keywords:  Checkerboard assay; Drug interactions; Drug synergy

Mesh：

Substances：

Year:  2019        PMID： 30848453     DOI： 10.1007/978-1-4939-9089-4_1

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  5 in total

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Review 2.  Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria.

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4.  Evaluation of JQ1 Combined With Docetaxel for the Treatment of Prostate Cancer Cells in 2D- and 3D-Culture Systems.

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5.  Antimicrobial and Antioxidant Potential of Scenedesmus obliquus Microalgae in the Context of Integral Biorefinery Concept.

Authors:  Maya Margaritova Zaharieva; Dimitrina Zheleva-Dimitrova; Snezhana Rusinova-Videva; Yana Ilieva; Anna Brachkova; Vessela Balabanova; Reneta Gevrenova; Tanya Chan Kim; Mila Kaleva; Almira Georgieva; Milka Mileva; Krassimira Yoncheva; Niko Benbassat; Hristo Najdenski; Alexander Dimitrov Kroumov
Journal:  Molecules       Date:  2022-01-14       Impact factor: 4.411
  5 in total

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