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Literature DB >> 30847896

Phase 1-2 safety, efficacy and pharmacokinetic study of decitabine in sequential administration with cytarabine in children with relapsed or refractory acute myeloid leukaemia.

Pamela Kearns¹, Christian M Zwaan², Dirk Reinhardt³, Brenda Gibson⁴, Lucas Moreno⁵, Karsten Nysom⁶, Susumu Nakahara⁷, Fei Huang⁸, Wangda Zhou⁸, Dolly A Parasrampuria⁸, Sepideh Nemat⁹.

Abstract

Entities: Chemical Disease Species

Keywords: zzm321990CDKN2Bzzm321990; zzm321990ESR1zzm321990; DNA methylation; acute myeloid leukaemia; cytarabine; decitabine

Mesh：

Substances：
Cytarabine
Decitabine

Year: 2019 PMID： 30847896 DOI： 10.1111/bjh.15847

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

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1 in total

1. Decitabine mildly attenuates MLL-rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo-sensitizer.

Authors: Pauline Schneider; Patricia Garrido Castro; Sandra M Pinhanços; Mark Kerstjens; Eddy H van Roon; Anke H W Essing; M Emmy M Dolman; Jan J Molenaar; Rob Pieters; Ronald W Stam
Journal: EJHaem Date: 2020-08-24

1 in total