Literature DB >> 3084782

Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens.

G Ferraccioli, F Peri, A Nervetti, U Ambanelli, M Savi.   

Abstract

Twenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 frequency was observed in patients with RA except for the Tiopronin related nephritis group.

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Year:  1986        PMID： 3084782

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  7 in total

Review 1.  Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.

Authors:  B K Park; M Pirmohamed; N R Kitteringham
Journal:  Br J Clin Pharmacol       Date:  1992-11       Impact factor: 4.335

2.  Similarity of the genetic background in rheumatic diseases between northern Italian and Israeli patients.

Authors:  G F Ferraccioli; G Bianchi; M Savi
Journal:  Ann Rheum Dis       Date:  1989-01       Impact factor: 19.103

3.  HLA-A33/B44/DR6 is highly related to intrahepatic cholestasis induced by tiopronin.

Authors:  M Kurosaki; H Takagi; M Mori
Journal:  Dig Dis Sci       Date:  2000-06       Impact factor: 3.199

4.  Association of HLA-B35 with mucocutaneous lesions in Israeli patients with rheumatoid arthritis receiving gold treatment.

Authors:  M Tishler; D Caspi; E Gazit; M Yaron
Journal:  Ann Rheum Dis       Date:  1988-03       Impact factor: 19.103

Review 5.  Conditional pharmacology/toxicology V: ambivalent effects of thiocyanate upon the development and the inhibition of experimental arthritis in rats by aurothiomalate (Myocrysin®) and metallic silver.

Authors:  Michael Whitehouse; Desley Butters; Barrie Vernon-Roberts
Journal:  Inflammopharmacology       Date:  2013-05-19       Impact factor: 4.473

6.  Association between gold induced skin rash and remission in patients with rheumatoid arthritis.

Authors:  D Caspi; M Tishler; M Yaron
Journal:  Ann Rheum Dis       Date:  1989-09       Impact factor: 19.103

7.  Immunogenetic and racial determinants of gold toxicity in rheumatoid arthritis.

Authors:  P A Fraser; S H Stern; J S Coblyn; M E Weinblatt; D E Holdsworth; P Green; S Shriner; D Mindnich; M Larson
Journal:  J Natl Med Assoc       Date:  1988-02       Impact factor: 1.798
  7 in total

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