Lediya Cheru1, Charles F Saylor1, Janet Lo2. 1. Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, LON-207, Boston, MA, 02114, USA. 2. Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, LON-207, Boston, MA, 02114, USA. jlo@mgh.harvard.edu.
Abstract
PURPOSE OF REVIEW: Obesity is a state of chronic inflammation. This review aims to summarize recent data supporting the role of the intestinal mucosal barrier and the microbiome in causing adipose tissue inflammation as well as metabolic factors that can affect the intestinal barrier. RECENT FINDINGS: Obesity and its metabolic consequences, such as diabetes mellitus, are associated with disruption of the intestinal barrier function. Intestinal microbiota and diet play a key role in the maintenance of a healthy intestinal epithelium. Intestinal barrier dysfunction can lead to heightened inflammation, which in turn can further damage the intestinal barrier through the disruption of tight junction proteins. Intestinal barrier breakdown is associated with adipose tissue inflammation in different disease states, such as obesity, diabetes mellitus, HIV, and inflammatory bowel disease. Future therapeutic strategies to ameliorate intestinal barrier function may help reduce inflammation in obesity and other chronic conditions of increased intestinal permeability.
PURPOSE OF REVIEW: Obesity is a state of chronic inflammation. This review aims to summarize recent data supporting the role of the intestinal mucosal barrier and the microbiome in causing adipose tissue inflammation as well as metabolic factors that can affect the intestinal barrier. RECENT FINDINGS:Obesity and its metabolic consequences, such as diabetes mellitus, are associated with disruption of the intestinal barrier function. Intestinal microbiota and diet play a key role in the maintenance of a healthy intestinal epithelium. Intestinal barrier dysfunction can lead to heightened inflammation, which in turn can further damage the intestinal barrier through the disruption of tight junction proteins. Intestinal barrier breakdown is associated with adipose tissue inflammation in different disease states, such as obesity, diabetes mellitus, HIV, and inflammatory bowel disease. Future therapeutic strategies to ameliorate intestinal barrier function may help reduce inflammation in obesity and other chronic conditions of increased intestinal permeability.
Authors: P Desreumaux; O Ernst; K Geboes; L Gambiez; D Berrebi; H Müller-Alouf; S Hafraoui; D Emilie; N Ectors; M Peuchmaur; A Cortot; M Capron; J Auwerx; J F Colombel Journal: Gastroenterology Date: 1999-07 Impact factor: 22.682
Authors: Patrice D Cani; Jacques Amar; Miguel Angel Iglesias; Marjorie Poggi; Claude Knauf; Delphine Bastelica; Audrey M Neyrinck; Francesca Fava; Kieran M Tuohy; Chantal Chabo; Aurélie Waget; Evelyne Delmée; Béatrice Cousin; Thierry Sulpice; Bernard Chamontin; Jean Ferrières; Jean-François Tanti; Glenn R Gibson; Louis Casteilla; Nathalie M Delzenne; Marie Christine Alessi; Rémy Burcelin Journal: Diabetes Date: 2007-04-24 Impact factor: 9.461
Authors: Anna M Wolf; Dominik Wolf; Holger Rumpold; Barbara Enrich; Herbert Tilg Journal: Biochem Biophys Res Commun Date: 2004-10-15 Impact factor: 3.575
Authors: Peter Suenaert; Veerle Bulteel; Liesbeth Lemmens; Maja Noman; Benny Geypens; Gert Van Assche; Karel Geboes; Jan L Ceuppens; Paul Rutgeerts Journal: Am J Gastroenterol Date: 2002-08 Impact factor: 10.864
Authors: Jason M Brenchley; David A Price; Timothy W Schacker; Tedi E Asher; Guido Silvestri; Srinivas Rao; Zachary Kazzaz; Ethan Bornstein; Olivier Lambotte; Daniel Altmann; Bruce R Blazar; Benigno Rodriguez; Leia Teixeira-Johnson; Alan Landay; Jeffrey N Martin; Frederick M Hecht; Louis J Picker; Michael M Lederman; Steven G Deeks; Daniel C Douek Journal: Nat Med Date: 2006-11-19 Impact factor: 53.440
Authors: Rim Ben Necib; Claudia Manca; Sébastien Lacroix; Cyril Martin; Nicolas Flamand; Vincenzo Di Marzo; Cristoforo Silvestri Journal: Front Immunol Date: 2022-09-26 Impact factor: 8.786