Literature DB >> 30846468

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report.

Vanessa M McDonald1,2, James Fingleton3,4, Alvar Agusti5, Sarah A Hiles1, Vanessa L Clark6, Anne E Holland7, Guy B Marks8,9, Philip P Bardin10, Richard Beasley3,4, Ian D Pavord11, Peter A B Wark1,2, Peter G Gibson1,2.   

Abstract

"Treatable traits" have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.
Copyright ©ERS 2019.

Mesh:

Year:  2019        PMID: 30846468     DOI: 10.1183/13993003.02058-2018

Source DB:  PubMed          Journal:  Eur Respir J        ISSN: 0903-1936            Impact factor:   16.671


  42 in total

1.  Management of severe asthma: from stepwise approach to therapy to treatable traits?

Authors:  Gang Wang; Vanessa M McDonald; Peter G Gibson
Journal:  Precis Clin Med       Date:  2021-12-03

2.  Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease.

Authors:  Sara Souto-Miranda; Alex J van 't Hul; Anouk W Vaes; Jeanine C Antons; Remco S Djamin; Daisy J A Janssen; Frits M E Franssen; Alda Marques; Martijn A Spruit
Journal:  J Clin Med       Date:  2022-06-26       Impact factor: 4.964

3.  Using a knowledge translation framework to identify health care professionals' perceived barriers and enablers for personalised severe asthma care.

Authors:  Eleanor C Majellano; Vanessa L Clark; Rebecca F McLoughlin; Peter G Gibson; Vanessa M McDonald
Journal:  PLoS One       Date:  2022-06-07       Impact factor: 3.752

4.  Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study.

Authors:  Nina Faksvåg Caspersen; Vidar Søyseth; Magnus Nakrem Lyngbakken; Trygve Berge; Inger Ariansen; Arnljot Tveit; Helge Røsjø; Gunnar Einvik
Journal:  Chronic Obstr Pulm Dis       Date:  2022-04-29

5.  Treatable Mechanisms in Asthma.

Authors:  Mario Cazzola; Josuel Ora; Francesco Cavalli; Paola Rogliani; Maria Gabriella Matera
Journal:  Mol Diagn Ther       Date:  2021-02-11       Impact factor: 4.074

Review 6.  Single inhaler triple therapy (SITT) in asthma: Systematic review and practice implications.

Authors:  Alvar Agusti; Leonardo Fabbri; Lies Lahousse; Dave Singh; Alberto Papi
Journal:  Allergy       Date:  2021-09-15       Impact factor: 14.710

7.  Approaches to the assessment of severe asthma: barriers and strategies.

Authors:  Eleanor C Majellano; Vanessa L Clark; Natasha A Winter; Peter G Gibson; Vanessa M McDonald
Journal:  J Asthma Allergy       Date:  2019-08-23

8.  Understanding reliever overuse in patients purchasing over-the-counter short-acting beta2 agonists: an Australian community pharmacy-based survey.

Authors:  Elizabeth A Azzi; Vicky Kritikos; Matthew J Peters; David B Price; Pamela Srour; Biljana Cvetkovski; Sinthia Bosnic-Anticevich
Journal:  BMJ Open       Date:  2019-08-14       Impact factor: 2.692

Review 9.  Mepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions.

Authors:  Peter G Gibson; Charlene M Prazma; Geoffrey L Chupp; Eric S Bradford; Mark Forshag; Stephen A Mallett; Steve W Yancey; Steven G Smith; Elisabeth H Bel
Journal:  Respir Res       Date:  2021-06-07

Review 10.  Challenges to the Application of Integrated, Personalized Care for Patients with COPD-A Vision for the Role of Clinical Information.

Authors:  Lowie E G W Vanfleteren; Alex J van 't Hul; Katarzyna Kulbacka-Ortiz; Anders Andersson; Anders Ullman; Martin Ingvar
Journal:  J Clin Med       Date:  2020-05-02       Impact factor: 4.241

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