BACKGROUND: For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2-induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T-cell and B-cell subsets, which we aimed to characterize further. METHODS: From an HIV clinic in Guinea-Bissau, 63 HIV-2, 83 HIV-1, and 26 HIV-negative participants were included. All HIV-infected participants were ART-naive. The following cell subsets were analysed by flow cytometry; T cells (maturation and activation), regulatory T cells, and B cells (maturation and activation). RESULTS: After standardizing for sex, age, and CD4 T-cell count HIV-2 had 0.938 log10 copies/ml lower HIV RNA levels than the HIV-1-infected patients. Whereas T-cell maturation and regulatory T-cell profiles were similar between patients, HIV-2-infected patients had higher proportions of CD8CD28 and lower proportions of CD8PD-1+ T cells than HIV-1-infected patients. This finding was independent of HIV RNA levels. HIV-2 was also associated with a more preserved proportion of naive B cells. CONCLUSION: HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression.
BACKGROUND: For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2-induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T-cell and B-cell subsets, which we aimed to characterize further. METHODS: From an HIV clinic in Guinea-Bissau, 63 HIV-2, 83 HIV-1, and 26 HIV-negative participants were included. All HIV-infectedparticipants were ART-naive. The following cell subsets were analysed by flow cytometry; T cells (maturation and activation), regulatory T cells, and B cells (maturation and activation). RESULTS: After standardizing for sex, age, and CD4 T-cell count HIV-2 had 0.938 log10 copies/ml lower HIV RNA levels than the HIV-1-infectedpatients. Whereas T-cell maturation and regulatory T-cell profiles were similar between patients, HIV-2-infectedpatients had higher proportions of CD8CD28 and lower proportions of CD8PD-1+ T cells than HIV-1-infectedpatients. This finding was independent of HIV RNA levels. HIV-2 was also associated with a more preserved proportion of naive B cells. CONCLUSION:HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression.
Authors: Joakim Esbjörnsson; Marianne Jansson; Sanne Jespersen; Fredrik Månsson; Bo L Hønge; Jacob Lindman; Candida Medina; Zacarias J da Silva; Hans Norrgren; Patrik Medstrand; Sarah L Rowland-Jones; Christian Wejse Journal: AIDS Res Ther Date: 2019-09-05 Impact factor: 2.250
Authors: Sivasankaran Munusamy Ponnan; K K Vidyavijayan; Kannan Thiruvengadam; Nancy Hilda J; Manikannan Mathayan; Kailapuri Gangatharan Murugavel; Luke Elizabeth Hanna Journal: Front Immunol Date: 2021-04-16 Impact factor: 7.561
Authors: Lydia Scharf; Christina B Pedersen; Emil Johansson; Jacob Lindman; Lars R Olsen; Marcus Buggert; Sten Wilhelmson; Fredrik Månsson; Joakim Esbjörnsson; Antonio Biague; Patrik Medstrand; Hans Norrgren; Annika C Karlsson; Marianne Jansson Journal: Front Immunol Date: 2021-10-12 Impact factor: 7.561
Authors: Emil Johansson; Priscilla F Kerkman; Lydia Scharf; Jacob Lindman; Zsófia I Szojka; Fredrik Månsson; Antonio Biague; Patrik Medstrand; Hans Norrgren; Marcus Buggert; Annika C Karlsson; Mattias N E Forsell; Joakim Esbjörnsson; Marianne Jansson Journal: Cells Date: 2022-10-06 Impact factor: 7.666