Maria Krutikov1, Ananna Rahman2, Simon Tiberi1,3. 1. Division of Infection, The Royal London Hospital. 2. Department of Respiratory Medicine, Barts Health NHS Trust. 3. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK.
Abstract
PURPOSE OF REVIEW: Necrotizing pneumonia is a severe form of community-acquired pneumonia characterized by rapid progression of consolidation to necrosis and cavitation which may lead to pulmonary gangrene. Morbidity and mortality are high and chronic sequelae are frequent. The lack of guidance supports the review of the latest recommendations in the management of these pneumonias. RECENT FINDINGS: Antibiotic therapy alone may not be enough to alter the course of the infection, and regimens, adjunctive therapies like intravenous immunoglobulins, surgery may be required to alter the course of the disease especially with pulmonary gangrene. SUMMARY: The causative agents, clinical features and management of necrotizing pneumonias are discussed.
PURPOSE OF REVIEW: Necrotizing pneumonia is a severe form of community-acquired pneumonia characterized by rapid progression of consolidation to necrosis and cavitation which may lead to pulmonary gangrene. Morbidity and mortality are high and chronic sequelae are frequent. The lack of guidance supports the review of the latest recommendations in the management of these pneumonias. RECENT FINDINGS: Antibiotic therapy alone may not be enough to alter the course of the infection, and regimens, adjunctive therapies like intravenous immunoglobulins, surgery may be required to alter the course of the disease especially with pulmonary gangrene. SUMMARY: The causative agents, clinical features and management of necrotizing pneumonias are discussed.
Authors: Elisabeth M Liebler-Tenorio; Jacqueline Lambertz; Carola Ostermann; Konrad Sachse; Petra Reinhold Journal: Int J Mol Sci Date: 2020-04-17 Impact factor: 5.923