Ala Litman-Zawadzka1, Marta Łukaszewicz-Zając2, Barbara Mroczko3. 1. Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland. 2. Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland. 3. Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland; Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland. Electronic address: mroczko@umb.edu.pl.
Abstract
BACKGROUND: It is estimated that in developed countries the incidence rate of pancreatic cancer (PC) will continue to rise and by 2020 will be the second most fatal cancer. The mortality of PC patients closely parallels the incidence rate, as this malignancy remains asymptomatic until it reaches an advanced stage of disease. Thus, novel biochemical markers that improve the management of PC patients are necessary. The aim of the work that follows is to investigate whether selected inflammatory mediators might be used in the diagnosis of PC, with the aim of improving the prognosis for PC patients. METHODS: We performed a thorough search for literature pertaining to our investigation via the MEDLINE/PubMed database. RESULTS: It has been proved that certain inflammatory mediators might be involved in tumor progression, such as growth, proliferation, migration and angiogenesis of tumor cells. In the present review, we summarized and referred to a number of original papers concerning the clinical significance of selected cytokines and specific inflammatory proteins such as C-reactive protein, as well as of various matrix metalloproteinases and their tissue inhibitors, as potential biomarkers for PC in comparison to well-established tumor markers for this malignancy. CONCLUSION: Presented proteins might be potential biomarkers in the diagnosis and progression of PC.
BACKGROUND: It is estimated that in developed countries the incidence rate of pancreatic cancer (PC) will continue to rise and by 2020 will be the second most fatal cancer. The mortality of PC patients closely parallels the incidence rate, as this malignancy remains asymptomatic until it reaches an advanced stage of disease. Thus, novel biochemical markers that improve the management of PC patients are necessary. The aim of the work that follows is to investigate whether selected inflammatory mediators might be used in the diagnosis of PC, with the aim of improving the prognosis for PC patients. METHODS: We performed a thorough search for literature pertaining to our investigation via the MEDLINE/PubMed database. RESULTS: It has been proved that certain inflammatory mediators might be involved in tumor progression, such as growth, proliferation, migration and angiogenesis of tumor cells. In the present review, we summarized and referred to a number of original papers concerning the clinical significance of selected cytokines and specific inflammatory proteins such as C-reactive protein, as well as of various matrix metalloproteinases and their tissue inhibitors, as potential biomarkers for PC in comparison to well-established tumor markers for this malignancy. CONCLUSION: Presented proteins might be potential biomarkers in the diagnosis and progression of PC.
Authors: Sugandha Saxena; Caitlin Molczyk; Abhilasha Purohit; Evie Ehrhorn; Paran Goel; Dipakkumar R Prajapati; Pranita Atri; Sukhwinder Kaur; Paul M Grandgenett; Michael A Hollingsworth; Surinder K Batra; Rakesh K Singh Journal: Am J Cancer Res Date: 2022-01-15 Impact factor: 6.166