Zahra Cheraghi1, Amin Doosti-Irani2, Amir Almasi-Hashiani3, Vali Baigi4, Nasrin Mansournia5, Mahyar Etminan6, Mohammad Ali Mansournia7. 1. Department of Epidemiology, Research Center of Modeling of Non-Communicable Disease, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: cheraghiz@ymail.com. 2. Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: a_doostiirani@yahoo.com. 3. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address: amiralmasi2007@gmail.com. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: v-baigi@razi.tums.ac.ir. 5. Department of Endocrinology, AJA University of Medical Sciences, Tehran, Iran. Electronic address: nasrin_sept@yahoo.com. 6. Department of Ophthalmology and Visual Sciences, The Eye Care Center, University of British Columbia, Room 323-2550 Willow Street, Vancouver BC, V5Z 3N9, Canada. Electronic address: etminanm@mail.ubc.ca. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, 6517838695, Iran. Electronic address: mansournia_ma@yahoo.com.
Abstract
BACKGROUND: Osteoporosis is a multifactorial disease hallmarked by the interaction of genetic, nutritional and environmental factors. We aimed to assess the effect of alcohol consumption on the osteoporosis by undertaking a systematic review and meta-analysis. METHODS: We searched electronic databases including MEDLINE, Scopus, and Web of Science until June 2018. We identified all pertinent observational studies that examined the risk of OSTEOPOROSIS with alcohol use including cohort, case-control and cross-sectional studies. Relative risks (RR) for cohort studies and odds ratios (ORs) for case-control studies were pooled using the random effects model. Risk of bias was assessed using the Newcastle-Ottawa scale. RESULTS: From a pool of 3479 studies identified six met the study inclusion criteria (three case control, two cohorts and one cross-sectional study). Compared with abstainers of alcohol, persons consuming 0.5-1 drinks per day had 1.38 times the risk of developing osteoporosis (adjusted RR = 1.38, 95% CI: 0.90-2.12), persons consuming 1-2 drinks per day had 1.34 times the risk of developing OSTEOPOROSIS (adjusted RR = 1.34, 95% CI: 1.11-1.62), and persons consuming two drinks or more per day had 1.63 times the risk of developing osteoporosis (adjusted RR = 1.63, 95% CI: 1.01-2.65). We found a positive association between alcohol consumption and osteoporosis in the case-control studies (adjusted OR = 2.95, 95% CI: 1.78-4.90). CONCLUSION: Our study demonstrates a positive relationship between alcohol consumption and osteoporosis.
BACKGROUND:Osteoporosis is a multifactorial disease hallmarked by the interaction of genetic, nutritional and environmental factors. We aimed to assess the effect of alcohol consumption on the osteoporosis by undertaking a systematic review and meta-analysis. METHODS: We searched electronic databases including MEDLINE, Scopus, and Web of Science until June 2018. We identified all pertinent observational studies that examined the risk of OSTEOPOROSIS with alcohol use including cohort, case-control and cross-sectional studies. Relative risks (RR) for cohort studies and odds ratios (ORs) for case-control studies were pooled using the random effects model. Risk of bias was assessed using the Newcastle-Ottawa scale. RESULTS: From a pool of 3479 studies identified six met the study inclusion criteria (three case control, two cohorts and one cross-sectional study). Compared with abstainers of alcohol, persons consuming 0.5-1 drinks per day had 1.38 times the risk of developing osteoporosis (adjusted RR = 1.38, 95% CI: 0.90-2.12), persons consuming 1-2 drinks per day had 1.34 times the risk of developing OSTEOPOROSIS (adjusted RR = 1.34, 95% CI: 1.11-1.62), and persons consuming two drinks or more per day had 1.63 times the risk of developing osteoporosis (adjusted RR = 1.63, 95% CI: 1.01-2.65). We found a positive association between alcohol consumption and osteoporosis in the case-control studies (adjusted OR = 2.95, 95% CI: 1.78-4.90). CONCLUSION: Our study demonstrates a positive relationship between alcohol consumption and osteoporosis.
Authors: J Barnsley; G Buckland; P E Chan; A Ong; A S Ramos; M Baxter; F Laskou; E M Dennison; C Cooper; Harnish P Patel Journal: Aging Clin Exp Res Date: 2021-03-20 Impact factor: 3.636
Authors: Christian Horst Tonk; Sarah Hani Shoushrah; Patrick Babczyk; Basma El Khaldi-Hansen; Margit Schulze; Monika Herten; Edda Tobiasch Journal: Int J Mol Sci Date: 2022-01-26 Impact factor: 5.923
Authors: Anna Maria Rychter; Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Michał Michalak; Piotr Eder; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak Journal: Nutrients Date: 2021-05-30 Impact factor: 5.717
Authors: Flavia Kiweewa Matovu; Martin Nabwana; Noah Kiwanuka; Delia Scholes; Esther Isingel; Monica L Nolan; Mary G Fowler; Philippa Musoke; John M Pettifor; Todd T Brown; Mags E Beksinska Journal: JBMR Plus Date: 2020-12-21