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Literature DB >> 30844513

Organoid models for translational pancreatic cancer research.

Hervé Tiriac¹, Dennis Plenker², Lindsey A Baker², David A Tuveson³.

Abstract

Despite recent advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) still retains the worst survival rate of common malignancies. Late diagnosis and lack of curative therapeutic options are the most pressing clinical problems for this disease. Therefore, there is a need for patient models and biomarkers that can be applied in the clinic to identify the most effective therapy for a patient. Pancreatic ductal organoids are ex-vivo models of PDAC that can be established from very small biopsies, enabling the study of localized, advanced, and metastatic patients. Organoids models have been applied to pancreatic cancer research and offer a promising platform for precision medicine approaches.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2019 PMID： 30844513 PMCID： PMC6722026 DOI： 10.1016/j.gde.2019.02.003

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

55 in total

Review 1. Preclinical models of pancreatic ductal adenocarcinoma.

Authors: Benjamin D Krempley; Kenneth H Yu
Journal: Chin Clin Oncol Date: 2017-06

2. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.

Authors: Giulia Biffi; Tobiloba E Oni; Benjamin Spielman; Yuan Hao; Ela Elyada; Youngkyu Park; Jonathan Preall; David A Tuveson
Journal: Cancer Discov Date: 2018-10-26 Impact factor: 39.397

3. Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations.

Authors: Zishuo I Hu; Jinru Shia; Zsofia K Stadler; Anna M Varghese; Marinela Capanu; Erin Salo-Mullen; Maeve A Lowery; Luis A Diaz; Diana Mandelker; Kenneth H Yu; Alice Zervoudakis; David P Kelsen; Christine A Iacobuzio-Donahue; David S Klimstra; Leonard B Saltz; Ibrahim H Sahin; Eileen M O'Reilly
Journal: Clin Cancer Res Date: 2018-01-24 Impact factor: 12.531

4. Organoid models of human and mouse ductal pancreatic cancer.

Authors: Sylvia F Boj; Chang-Il Hwang; Lindsey A Baker; Iok In Christine Chio; Dannielle D Engle; Vincenzo Corbo; Myrthe Jager; Mariano Ponz-Sarvise; Hervé Tiriac; Mona S Spector; Ana Gracanin; Tobiloba Oni; Kenneth H Yu; Ruben van Boxtel; Meritxell Huch; Keith D Rivera; John P Wilson; Michael E Feigin; Daniel Öhlund; Abram Handly-Santana; Christine M Ardito-Abraham; Michael Ludwig; Ela Elyada; Brinda Alagesan; Giulia Biffi; Georgi N Yordanov; Bethany Delcuze; Brianna Creighton; Kevin Wright; Youngkyu Park; Folkert H M Morsink; I Quintus Molenaar; Inne H Borel Rinkes; Edwin Cuppen; Yuan Hao; Ying Jin; Isaac J Nijman; Christine Iacobuzio-Donahue; Steven D Leach; Darryl J Pappin; Molly Hammell; David S Klimstra; Olca Basturk; Ralph H Hruban; George Johan Offerhaus; Robert G J Vries; Hans Clevers; David A Tuveson
Journal: Cell Date: 2014-12-31 Impact factor: 41.582

5. Whole genomes redefine the mutational landscape of pancreatic cancer.

Authors: Nicola Waddell; Marina Pajic; Ann-Marie Patch; David K Chang; Karin S Kassahn; Peter Bailey; Amber L Johns; David Miller; Katia Nones; Kelly Quek; Michael C J Quinn; Alan J Robertson; Muhammad Z H Fadlullah; Tim J C Bruxner; Angelika N Christ; Ivon Harliwong; Senel Idrisoglu; Suzanne Manning; Craig Nourse; Ehsan Nourbakhsh; Shivangi Wani; Peter J Wilson; Emma Markham; Nicole Cloonan; Matthew J Anderson; J Lynn Fink; Oliver Holmes; Stephen H Kazakoff; Conrad Leonard; Felicity Newell; Barsha Poudel; Sarah Song; Darrin Taylor; Nick Waddell; Scott Wood; Qinying Xu; Jianmin Wu; Mark Pinese; Mark J Cowley; Hong C Lee; Marc D Jones; Adnan M Nagrial; Jeremy Humphris; Lorraine A Chantrill; Venessa Chin; Angela M Steinmann; Amanda Mawson; Emily S Humphrey; Emily K Colvin; Angela Chou; Christopher J Scarlett; Andreia V Pinho; Marc Giry-Laterriere; Ilse Rooman; Jaswinder S Samra; James G Kench; Jessica A Pettitt; Neil D Merrett; Christopher Toon; Krishna Epari; Nam Q Nguyen; Andrew Barbour; Nikolajs Zeps; Nigel B Jamieson; Janet S Graham; Simone P Niclou; Rolf Bjerkvig; Robert Grützmann; Daniela Aust; Ralph H Hruban; Anirban Maitra; Christine A Iacobuzio-Donahue; Christopher L Wolfgang; Richard A Morgan; Rita T Lawlor; Vincenzo Corbo; Claudio Bassi; Massimo Falconi; Giuseppe Zamboni; Giampaolo Tortora; Margaret A Tempero; Anthony J Gill; James R Eshleman; Christian Pilarsky; Aldo Scarpa; Elizabeth A Musgrove; John V Pearson; Andrew V Biankin; Sean M Grimmond
Journal: Nature Date: 2015-02-26 Impact factor: 49.962

6. Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.

Authors: Lindsey A Baker; Hervé Tiriac; David A Tuveson
Journal: Methods Mol Biol Date: 2019

7. Long-term culture of genome-stable bipotent stem cells from adult human liver.

Authors: Meritxell Huch; Helmuth Gehart; Ruben van Boxtel; Karien Hamer; Francis Blokzijl; Monique M A Verstegen; Ewa Ellis; Martien van Wenum; Sabine A Fuchs; Joep de Ligt; Marc van de Wetering; Nobuo Sasaki; Susanne J Boers; Hans Kemperman; Jeroen de Jonge; Jan N M Ijzermans; Edward E S Nieuwenhuis; Ruurdtje Hoekstra; Stephen Strom; Robert R G Vries; Luc J W van der Laan; Edwin Cuppen; Hans Clevers
Journal: Cell Date: 2014-12-18 Impact factor: 41.582

8. Tissue-specific mutation accumulation in human adult stem cells during life.

Authors: Francis Blokzijl; Joep de Ligt; Myrthe Jager; Valentina Sasselli; Sophie Roerink; Nobuo Sasaki; Meritxell Huch; Sander Boymans; Ewart Kuijk; Pjotr Prins; Isaac J Nijman; Inigo Martincorena; Michal Mokry; Caroline L Wiegerinck; Sabine Middendorp; Toshiro Sato; Gerald Schwank; Edward E S Nieuwenhuis; Monique M A Verstegen; Luc J W van der Laan; Jeroen de Jonge; Jan N M IJzermans; Robert G Vries; Marc van de Wetering; Michael R Stratton; Hans Clevers; Edwin Cuppen; Ruben van Boxtel
Journal: Nature Date: 2016-10-03 Impact factor: 49.962

9. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.

Authors: Richard A Moffitt; Raoud Marayati; Elizabeth L Flate; Keith E Volmar; S Gabriela Herrera Loeza; Katherine A Hoadley; Naim U Rashid; Lindsay A Williams; Samuel C Eaton; Alexander H Chung; Jadwiga K Smyla; Judy M Anderson; Hong Jin Kim; David J Bentrem; Mark S Talamonti; Christine A Iacobuzio-Donahue; Michael A Hollingsworth; Jen Jen Yeh
Journal: Nat Genet Date: 2015-09-07 Impact factor: 38.330

Review 10. Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer.

Authors: Leticia Moreira; Basil Bakir; Priya Chatterji; Zahra Dantes; Maximilian Reichert; Anil K Rustgi
Journal: Cell Mol Gastroenterol Hepatol Date: 2017-12-16

20 in total

1. Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas.

Authors: Francisca Beato; Dayana Reverón; Kaleena B Dezsi; Antonio Ortiz; Joseph O Johnson; Dung-Tsa Chen; Karla Ali; Sean J Yoder; Daniel Jeong; Mokenge Malafa; Pamela Hodul; Kun Jiang; Barbara A Centeno; Mahmoud A Abdalah; Jodi A Balasi; Alexandra F Tassielli; Bhaswati Sarcar; Jamie K Teer; Gina M DeNicola; Jennifer B Permuth; Jason B Fleming
Journal: Lab Invest Date: 2020-10-09 Impact factor: 5.662

2. Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids.

Authors: Krzysztof Wrzesinski; Helle Sedighi Frandsen; Carlemi Calitz; Chrisna Gouws; Barbara Korzeniowska; Stephen J Fey
Journal: Methods Mol Biol Date: 2021

Review 10. Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer.

Authors: Ashenafi Bulle; Kian-Huat Lim
Journal: Signal Transduct Target Ther Date: 2020-10-30

Organoid models for translational pancreatic cancer research.

Review 1. Preclinical models of pancreatic ductal adenocarcinoma.

2. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.

3. Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations.

4. Organoid models of human and mouse ductal pancreatic cancer.

5. Whole genomes redefine the mutational landscape of pancreatic cancer.

6. Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.

7. Long-term culture of genome-stable bipotent stem cells from adult human liver.

8. Tissue-specific mutation accumulation in human adult stem cells during life.

9. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.

Review 10. Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer.

1. Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas.

2. Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids.

Review 3. The Potential of Pancreatic Organoids for Diabetes Research and Therapy.

Review 4. Precision medicine in pancreatic cancer: treating every patient as an exception.

Review 5. Human organoids: model systems for human biology and medicine.

Review 6. Ping-Pong-Tumor and Host in Pancreatic Cancer Progression.

Review 7. Bioinformatics and computational approaches for analyzing patient-derived disease models in cancer research.

Review 8. Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies.

9. Analysis of lncRNA-mRNA networks after MEK1/2 inhibition based on WGCNA in pancreatic ductal adenocarcinoma.

Review 10. Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer.