Literature DB >> 30844401

A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward.

Michaël E Belloy1, Valerio Napolioni1, Michael D Greicius2.   

Abstract

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however, by lingering uncertainty over how to treat the quasi "monogenic" role of apolipoprotein E (APOE). The APOE4 allele is not only the strongest genetic risk factor for AD, it also affects risk for cardiovascular disease, stroke, and other neurodegenerative disorders. This review, based mostly on data from human studies, ranges across a variety of APOE-related pathologies, touching on evolutionary genetics and risk mitigation by ethnicity and sex. The authors also address one of the most fundamental question pertaining to APOE4 and AD: does APOE4 increase AD risk via a loss or gain of function? The answer will be of the utmost importance in guiding future research in AD.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  AD; APOE; ASO; Alzheimer’s disease; Apolipoprotein E; anti-sense oligonucleotide; cardiovascular disease; ethnicity; evolutionary genetics; gene-based therapy; neurodegenerative disease; pleiotropy; sex

Mesh：

Substances：

Year:  2019        PMID： 30844401      PMCID： PMC6407643          DOI： 10.1016/j.neuron.2019.01.056

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  242 in total

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Journal:  J Exp Zool       Date:  2001-08-01

2.  Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease.

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3.  Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide.

Authors:  Josep Saura; Valerie Petegnief; Xin Wu; Yanbin Liang; Steven M Paul
Journal:  J Neurochem       Date:  2003-06       Impact factor: 5.372

4.  Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation.

Authors:  Mitsuru Shinohara; Ronald C Petersen; Dennis W Dickson; Guojun Bu
Journal:  Acta Neuropathol       Date:  2013-01-31       Impact factor: 17.088

Review 5.  The role of apolipoprotein E in Alzheimer's disease.

Authors:  Jungsu Kim; Jacob M Basak; David M Holtzman
Journal:  Neuron       Date:  2009-08-13       Impact factor: 17.173

Review 6.  Antisense oligonucleotides: the next frontier for treatment of neurological disorders.

Authors:  Carlo Rinaldi; Matthew J A Wood
Journal:  Nat Rev Neurol       Date:  2017-12-01       Impact factor: 42.937

7.  A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

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Journal:  Neuron       Date:  2011-09-21       Impact factor: 17.173

Review 8.  Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

Authors:  Ian G McKeith; Bradley F Boeve; Dennis W Dickson; Glenda Halliday; John-Paul Taylor; Daniel Weintraub; Dag Aarsland; James Galvin; Johannes Attems; Clive G Ballard; Ashley Bayston; Thomas G Beach; Frédéric Blanc; Nicolaas Bohnen; Laura Bonanni; Jose Bras; Patrik Brundin; David Burn; Alice Chen-Plotkin; John E Duda; Omar El-Agnaf; Howard Feldman; Tanis J Ferman; Dominic Ffytche; Hiroshige Fujishiro; Douglas Galasko; Jennifer G Goldman; Stephen N Gomperts; Neill R Graff-Radford; Lawrence S Honig; Alex Iranzo; Kejal Kantarci; Daniel Kaufer; Walter Kukull; Virginia M Y Lee; James B Leverenz; Simon Lewis; Carol Lippa; Angela Lunde; Mario Masellis; Eliezer Masliah; Pamela McLean; Brit Mollenhauer; Thomas J Montine; Emilio Moreno; Etsuro Mori; Melissa Murray; John T O'Brien; Sotoshi Orimo; Ronald B Postuma; Shankar Ramaswamy; Owen A Ross; David P Salmon; Andrew Singleton; Angela Taylor; Alan Thomas; Pietro Tiraboschi; Jon B Toledo; John Q Trojanowski; Debby Tsuang; Zuzana Walker; Masahito Yamada; Kenji Kosaka
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9.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

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Journal:  Nat Genet       Date:  2013-10-27       Impact factor: 38.330

10.  APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.

Authors:  J I Vélez; F Lopera; D Sepulveda-Falla; H R Patel; A S Johar; A Chuah; C Tobón; D Rivera; A Villegas; Y Cai; K Peng; R Arkell; F X Castellanos; S J Andrews; M F Silva Lara; P K Creagh; S Easteal; J de Leon; M L Wong; J Licinio; C A Mastronardi; M Arcos-Burgos
Journal:  Mol Psychiatry       Date:  2015-12-01       Impact factor: 15.992
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  116 in total

1.  Apolipoprotein ɛ4 Allele and Subjective Cognitive Functioning in Parents of Adults With Disabilities.

Authors:  Jieun Song; Marsha R Mailick; Jan S Greenberg
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2020-09-14       Impact factor: 4.077

Review 2.  The genetics of human ageing.

Authors:  David Melzer; Luke C Pilling; Luigi Ferrucci
Journal:  Nat Rev Genet       Date:  2019-11-05       Impact factor: 53.242

3.  Dampening the Power of the Brain-When Aging Meets Cognition.

Authors:  Jeremy M Shea; Saul A Villeda
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2020-09-16       Impact factor: 6.053

4.  Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.

Authors:  Chelsea C Hays; Zvinka Z Zlatar; M J Meloy; Jessica Osuna; Thomas T Liu; Douglas R Galasko; Christina E Wierenga
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

5.  Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.

Authors:  Michael E Belloy; Valerio Napolioni; Summer S Han; Yann Le Guen; Michael D Greicius
Journal:  JAMA Neurol       Date:  2020-07-01       Impact factor: 18.302

Review 6.  The path to biomarker-based diagnostic criteria for the spectrum of neurodegenerative diseases.

Authors:  Filippo Baldacci; Sonia Mazzucchi; Alessandra Della Vecchia; Linda Giampietri; Nicola Giannini; Maya Koronyo-Hamaoui; Roberto Ceravolo; Gabriele Siciliano; Ubaldo Bonuccelli; Fanny M Elahi; Andrea Vergallo; Simone Lista; Filippo Sean Giorgi; Harald Hampel
Journal:  Expert Rev Mol Diagn       Date:  2020-02-27       Impact factor: 5.225

7.  APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.

Authors:  Annah M Moore; Emily Mahoney; Logan Dumitrescu; Philip L De Jager; Mary Ellen I Koran; Vladislav A Petyuk; Renã As Robinson; Douglas M Ruderfer; Nancy J Cox; Julie A Schneider; David A Bennett; Angela L Jefferson; Timothy J Hohman
Journal:  Neurobiol Aging       Date:  2019-11-05       Impact factor: 4.673

Review 8.  Genetic testing in dementia - utility and clinical strategies.

Authors:  Carolin A M Koriath; Joanna Kenny; Natalie S Ryan; Jonathan D Rohrer; Jonathan M Schott; Henry Houlden; Nick C Fox; Sarah J Tabrizi; Simon Mead
Journal:  Nat Rev Neurol       Date:  2020-11-09       Impact factor: 42.937

9.  A Likelihood Ratio Test for Gene-Environment Interaction Based on the Trend Effect of Genotype Under an Additive Risk Model Using the Gene-Environment Independence Assumption.

Authors:  Matthieu de Rochemonteix; Valerio Napolioni; Nilotpal Sanyal; Michaël E Belloy; Neil E Caporaso; Maria T Landi; Michael D Greicius; Nilanjan Chatterjee; Summer S Han
Journal:  Am J Epidemiol       Date:  2021-01-04       Impact factor: 4.897

10.  Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.

Authors:  Elizabeth E Blue; Timothy A Thornton; Charles Kooperberg; Simin Liu; Jean Wactawski-Wende; JoAnn Manson; Lew Kuller; Kathleen Hayden; Alexander P Reiner
Journal:  Alzheimers Dement       Date:  2020-09-23       Impact factor: 21.566
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